Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 3006229..3006700 | Replicon | chromosome |
| Accession | NZ_CP062769 | ||
| Organism | Escherichia coli O157:H7 strain Z852 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | ILQ33_RS15180 | Protein ID | WP_001303511.1 |
| Coordinates | 3006422..3006700 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | ILQ33_RS15175 | Protein ID | WP_001302048.1 |
| Coordinates | 3006229..3006420 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ILQ33_RS15135 | 3001436..3002020 | - | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
| ILQ33_RS15140 | 3002077..3002472 | - | 396 | WP_001118159.1 | DUF977 family protein | - |
| ILQ33_RS15145 | 3002488..3003257 | - | 770 | Protein_2964 | DUF1627 domain-containing protein | - |
| ILQ33_RS15150 | 3003283..3004023 | - | 741 | WP_000788938.1 | ATP-binding protein | - |
| ILQ33_RS15155 | 3004030..3004992 | - | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| ILQ33_RS15160 | 3005015..3005440 | - | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
| ILQ33_RS15165 | 3005437..3005739 | - | 303 | WP_000172738.1 | transcriptional regulator | - |
| ILQ33_RS15170 | 3005837..3006208 | + | 372 | WP_001169686.1 | hypothetical protein | - |
| ILQ33_RS15175 | 3006229..3006420 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| ILQ33_RS15180 | 3006422..3006700 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| ILQ33_RS15185 | 3007053..3007352 | + | 300 | WP_001240334.1 | hypothetical protein | - |
| ILQ33_RS15190 | 3007424..3007642 | + | 219 | WP_001171930.1 | hypothetical protein | - |
| ILQ33_RS15195 | 3008211..3008399 | + | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| ILQ33_RS15200 | 3008396..3008587 | + | 192 | WP_001090200.1 | DUF1482 family protein | - |
| ILQ33_RS15205 | 3008680..3011151 | + | 2472 | WP_072612735.1 | exonuclease | - |
| ILQ33_RS15210 | 3011216..3011464 | + | 249 | WP_000113189.1 | excisionase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | nleA/espI / galU | 2925919..3037294 | 111375 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T176399 WP_001303511.1 NZ_CP062769:3006422-3006700 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T176399 NZ_CP082799:c4592971-4592687 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT176399 WP_001302048.1 NZ_CP062769:3006229-3006420 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT176399 NZ_CP082799:c4593203-4592961 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|