Detailed information of TA system TA176334

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 3604328..3604806
• Replicon: chromosome
• Accession: NZ_CP062763
• Organism: Escherichia coli O157:H7 strain Z885

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A891SFN9
• Locus tag: ILQ36_RS18545
• Protein ID: WP_001303876.1
• Coordinates: 3604519..3604806 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: Q8XD67
• Locus tag: ILQ36_RS18540
• Protein ID: WP_000536233.1
• Coordinates: 3604328..3604519 (+)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ILQ36_RS18505	3599732..3600502	-	771	WP_000450992.1	DUF1627 domain-containing protein	-
ILQ36_RS18510	3600524..3601270	-	747	WP_000788751.1	ATP-binding protein	-
ILQ36_RS18515	3601277..3602368	-	1092	WP_001205823.1	hypothetical protein	-
ILQ36_RS18520	3602447..3602902	+	456	WP_000273724.1	hypothetical protein	-
ILQ36_RS18525	3603109..3603534	-	426	WP_000693855.1	Rha family transcriptional regulator	-
ILQ36_RS18530	3603518..3603790	-	273	WP_000887453.1	helix-turn-helix domain-containing protein	-
ILQ36_RS18535	3603899..3604300	+	402	WP_000986592.1	helix-turn-helix domain-containing protein	-
ILQ36_RS18540	3604328..3604519	+	192	WP_000536233.1	hypothetical protein	Antitoxin
ILQ36_RS18545	3604519..3604806	+	288	WP_001303876.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ILQ36_RS18550	3605084..3605239	+	156	WP_000379575.1	DUF1391 family protein	-
ILQ36_RS18555	3605381..3605770	+	390	WP_000394511.1	hypothetical protein	-
ILQ36_RS18560	3605957..3606142	-	186	WP_001133046.1	hypothetical protein	-
ILQ36_RS18565	3606716..3606904	+	189	WP_000413705.1	cell division inhibition protein DicB	-
ILQ36_RS18570	3606901..3607092	+	192	WP_001098307.1	DUF1482 family protein	-
ILQ36_RS18575	3607186..3609657	+	2472	WP_000034474.1	exonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10978.84 Da
• Isoelectric Point: 10.1360

>T176334 WP_001303876.1 NZ_CP062763:3604519-3604806 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Nucleotide

• Length: 288 bp

>T176334 NZ_CP082785:782129-782539 [Klebsiella quasipneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCTCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGCTGGTTCCCTGGCCGTTAAGCTACACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTTGACTGTG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGGCTGCGCTGGCAAAACGCC
GACTGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7025.80 Da
• Isoelectric Point: 4.0270

>AT176334 WP_000536233.1 NZ_CP062763:3604328-3604519 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Nucleotide

• Length: 192 bp

>AT176334 NZ_CP082785:781882-782148 [Klebsiella quasipneumoniae]
ATGGACATTAACAATAAAGCTCGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TATTCAACTGGCTGATGAACCATGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA