Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2726662..2727133 | Replicon | chromosome |
| Accession | NZ_CP062763 | ||
| Organism | Escherichia coli O157:H7 strain Z885 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | ILQ36_RS13810 | Protein ID | WP_001303511.1 |
| Coordinates | 2726855..2727133 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | ILQ36_RS13805 | Protein ID | WP_001302048.1 |
| Coordinates | 2726662..2726853 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ILQ36_RS13765 | 2721869..2722453 | - | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
| ILQ36_RS13770 | 2722510..2722905 | - | 396 | WP_001118159.1 | DUF977 family protein | - |
| ILQ36_RS13775 | 2722921..2723690 | - | 770 | Protein_2695 | DUF1627 domain-containing protein | - |
| ILQ36_RS13780 | 2723716..2724456 | - | 741 | WP_000788938.1 | ATP-binding protein | - |
| ILQ36_RS13785 | 2724463..2725425 | - | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| ILQ36_RS13790 | 2725448..2725873 | - | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
| ILQ36_RS13795 | 2725870..2726172 | - | 303 | WP_000172738.1 | transcriptional regulator | - |
| ILQ36_RS13800 | 2726270..2726641 | + | 372 | WP_001169686.1 | hypothetical protein | - |
| ILQ36_RS13805 | 2726662..2726853 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| ILQ36_RS13810 | 2726855..2727133 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| ILQ36_RS13815 | 2727486..2727785 | + | 300 | WP_001240334.1 | hypothetical protein | - |
| ILQ36_RS13820 | 2727857..2728075 | + | 219 | WP_001171930.1 | hypothetical protein | - |
| ILQ36_RS13825 | 2728644..2728832 | + | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| ILQ36_RS13830 | 2728829..2729020 | + | 192 | WP_001090200.1 | DUF1482 family protein | - |
| ILQ36_RS13835 | 2729113..2731584 | + | 2472 | WP_000048458.1 | exonuclease | - |
| ILQ36_RS13840 | 2731657..2731908 | + | 252 | WP_000005552.1 | excisionase family protein | - |
| ILQ36_RS13845 | 2731943..2732130 | + | 188 | Protein_2709 | DUF3596 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | nleA/espI | 2685597..2747141 | 61544 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T176322 WP_001303511.1 NZ_CP062763:2726855-2727133 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T176322 NZ_CP082777:c4088113-4087706 [Escherichia coli O25:H1]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT176322 WP_001302048.1 NZ_CP062763:2726662-2726853 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT176322 NZ_CP082777:c4088360-4088094 [Escherichia coli O25:H1]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTTTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTTTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|