Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 3044615..3045253 Replicon chromosome
Accession NZ_CP062761
Organism Escherichia coli O157:H7 strain Z887

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag ILQ37_RS15575 Protein ID WP_000813794.1
Coordinates 3045077..3045253 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag ILQ37_RS15570 Protein ID WP_001270286.1
Coordinates 3044615..3045031 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ37_RS15550 3039767..3040708 - 942 WP_001251315.1 ABC transporter permease -
ILQ37_RS15555 3040709..3041722 - 1014 WP_000220402.1 ABC transporter ATP-binding protein -
ILQ37_RS15560 3041740..3042885 - 1146 WP_000047432.1 ABC transporter substrate-binding protein -
ILQ37_RS15565 3043130..3044536 - 1407 WP_000760654.1 PLP-dependent aminotransferase family protein -
ILQ37_RS15570 3044615..3045031 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
ILQ37_RS15575 3045077..3045253 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
ILQ37_RS15580 3045475..3045705 + 231 WP_000494244.1 YncJ family protein -
ILQ37_RS15585 3045797..3047758 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
ILQ37_RS15590 3047831..3048367 - 537 WP_000429145.1 DNA-binding transcriptional regulator SutR -
ILQ37_RS15595 3048420..3049631 + 1212 WP_071525382.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T176292 WP_000813794.1 NZ_CP062761:c3045253-3045077 [Escherichia coli O157:H7]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T176292 NZ_CP082776:c807617-807465 [Escherichia coli O4:H5]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT176292 WP_001270286.1 NZ_CP062761:c3045031-3044615 [Escherichia coli O157:H7]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT176292 NZ_CP082776:807666-807723 [Escherichia coli O4:H5]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References