Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2570297..2570768 | Replicon | chromosome |
| Accession | NZ_CP062761 | ||
| Organism | Escherichia coli O157:H7 strain Z887 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | ILQ37_RS12885 | Protein ID | WP_001303511.1 |
| Coordinates | 2570297..2570575 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | ILQ37_RS12890 | Protein ID | WP_001302048.1 |
| Coordinates | 2570577..2570768 (-) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ILQ37_RS12850 | 2565303..2565487 | - | 185 | Protein_2508 | DUF3596 domain-containing protein | - |
| ILQ37_RS12855 | 2565522..2565773 | - | 252 | WP_000005552.1 | excisionase family protein | - |
| ILQ37_RS12860 | 2565846..2568317 | - | 2472 | WP_000048458.1 | exonuclease | - |
| ILQ37_RS12865 | 2568410..2568601 | - | 192 | WP_001090200.1 | DUF1482 family protein | - |
| ILQ37_RS12870 | 2568598..2568786 | - | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| ILQ37_RS12875 | 2569355..2569573 | - | 219 | WP_001171930.1 | hypothetical protein | - |
| ILQ37_RS12880 | 2569645..2569944 | - | 300 | WP_001240334.1 | hypothetical protein | - |
| ILQ37_RS12885 | 2570297..2570575 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| ILQ37_RS12890 | 2570577..2570768 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| ILQ37_RS12895 | 2570789..2571160 | - | 372 | WP_001169686.1 | hypothetical protein | - |
| ILQ37_RS12900 | 2571258..2571560 | + | 303 | WP_000172738.1 | transcriptional regulator | - |
| ILQ37_RS12905 | 2571557..2571982 | + | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
| ILQ37_RS12910 | 2572005..2572967 | + | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| ILQ37_RS12915 | 2572974..2573714 | + | 741 | WP_000788938.1 | ATP-binding protein | - |
| ILQ37_RS12920 | 2573740..2574509 | + | 770 | Protein_2522 | DUF1627 domain-containing protein | - |
| ILQ37_RS12925 | 2574525..2574920 | + | 396 | WP_001118159.1 | DUF977 family protein | - |
| ILQ37_RS12930 | 2574977..2575561 | + | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T176287 WP_001303511.1 NZ_CP062761:c2570575-2570297 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T176287 NZ_CP082775:c4692982-4692455 [Escherichia coli O25:H4]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT176287 WP_001302048.1 NZ_CP062761:c2570768-2570577 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT176287 NZ_CP082775:c4693255-4692989 [Escherichia coli O25:H4]
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|