Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2730126..2730597 | Replicon | chromosome |
| Accession | NZ_CP062755 | ||
| Organism | Escherichia coli O157:H7 strain Z903 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | ILQ39_RS13835 | Protein ID | WP_001303511.1 |
| Coordinates | 2730319..2730597 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | ILQ39_RS13830 | Protein ID | WP_001302048.1 |
| Coordinates | 2730126..2730317 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ILQ39_RS13790 | 2725333..2725917 | - | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
| ILQ39_RS13795 | 2725974..2726369 | - | 396 | WP_001118159.1 | DUF977 family protein | - |
| ILQ39_RS13800 | 2726385..2727154 | - | 770 | Protein_2700 | DUF1627 domain-containing protein | - |
| ILQ39_RS13805 | 2727180..2727920 | - | 741 | WP_000788938.1 | ATP-binding protein | - |
| ILQ39_RS13810 | 2727927..2728889 | - | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| ILQ39_RS13815 | 2728912..2729337 | - | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
| ILQ39_RS13820 | 2729334..2729636 | - | 303 | WP_000172738.1 | transcriptional regulator | - |
| ILQ39_RS13825 | 2729734..2730105 | + | 372 | WP_001169686.1 | hypothetical protein | - |
| ILQ39_RS13830 | 2730126..2730317 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| ILQ39_RS13835 | 2730319..2730597 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| ILQ39_RS13840 | 2730950..2731249 | + | 300 | WP_001240334.1 | hypothetical protein | - |
| ILQ39_RS13845 | 2731321..2731539 | + | 219 | WP_001171930.1 | hypothetical protein | - |
| ILQ39_RS13850 | 2732108..2732296 | + | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| ILQ39_RS13855 | 2732293..2732484 | + | 192 | WP_001090200.1 | DUF1482 family protein | - |
| ILQ39_RS13860 | 2732577..2735048 | + | 2472 | WP_000048458.1 | exonuclease | - |
| ILQ39_RS13865 | 2735121..2735372 | + | 252 | WP_000005552.1 | excisionase family protein | - |
| ILQ39_RS13870 | 2735407..2735594 | + | 188 | Protein_2714 | DUF3596 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | espK / espN / espN / espX7/nleL | 2594073..2737758 | 143685 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T176210 WP_001303511.1 NZ_CP062755:2730319-2730597 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T176210 NZ_CP082772:c828890-828549 [Escherichia coli O2:H1]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT176210 WP_001302048.1 NZ_CP062755:2730126-2730317 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT176210 NZ_CP082772:828885-828961 [Escherichia coli O2:H1]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|