Detailed information of TA system TA176150

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 3590113..3590591
• Replicon: chromosome
• Accession: NZ_CP062749
• Organism: Escherichia coli O157:H7 strain Z1486

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A891SFN9
• Locus tag: ILQ41_RS18460
• Protein ID: WP_001303876.1
• Coordinates: 3590304..3590591 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: Q8XD67
• Locus tag: ILQ41_RS18455
• Protein ID: WP_000536233.1
• Coordinates: 3590113..3590304 (+)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ILQ41_RS18420	3585528..3586298	-	771	WP_000450992.1	DUF1627 domain-containing protein	-
ILQ41_RS18425	3586320..3587066	-	747	WP_000788751.1	ATP-binding protein	-
ILQ41_RS18430	3587073..3588153	-	1081	Protein_3607	DNA-binding protein	-
ILQ41_RS18435	3588232..3588687	+	456	WP_000273724.1	hypothetical protein	-
ILQ41_RS18440	3588894..3589319	-	426	WP_000693855.1	Rha family transcriptional regulator	-
ILQ41_RS18445	3589303..3589575	-	273	WP_000887453.1	helix-turn-helix domain-containing protein	-
ILQ41_RS18450	3589684..3590085	+	402	WP_000986592.1	helix-turn-helix domain-containing protein	-
ILQ41_RS18455	3590113..3590304	+	192	WP_000536233.1	hypothetical protein	Antitoxin
ILQ41_RS18460	3590304..3590591	+	288	WP_001303876.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ILQ41_RS18465	3590869..3591024	+	156	WP_000379575.1	DUF1391 family protein	-
ILQ41_RS18470	3591166..3591555	+	390	WP_000394511.1	hypothetical protein	-
ILQ41_RS18475	3591742..3591927	-	186	WP_001133046.1	hypothetical protein	-
ILQ41_RS18480	3592501..3592689	+	189	WP_000413705.1	cell division inhibition protein DicB	-
ILQ41_RS18485	3592686..3592877	+	192	WP_001098307.1	DUF1482 family protein	-
ILQ41_RS18490	3592971..3595442	+	2472	WP_000034474.1	exonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10978.84 Da
• Isoelectric Point: 10.1360

>T176150 WP_001303876.1 NZ_CP062749:3590304-3590591 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Nucleotide

• Length: 288 bp

>T176150 NZ_CP082754:c120562-120119 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7025.80 Da
• Isoelectric Point: 4.0270

>AT176150 WP_000536233.1 NZ_CP062749:3590113-3590304 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Nucleotide

• Length: 192 bp

>AT176150 NZ_CP082754:c120789-120559 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA