Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
| Location | 1092996..1093579 | Replicon | chromosome |
| Accession | NZ_CP062749 | ||
| Organism | Escherichia coli O157:H7 strain Z1486 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | S1EZP4 |
| Locus tag | ILQ41_RS05295 | Protein ID | WP_000254738.1 |
| Coordinates | 1093244..1093579 (+) | Length | 112 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | S1P3W5 |
| Locus tag | ILQ41_RS05290 | Protein ID | WP_000581937.1 |
| Coordinates | 1092996..1093244 (+) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ILQ41_RS05280 | 1089335..1090636 | + | 1302 | WP_000046824.1 | 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD | - |
| ILQ41_RS05285 | 1090684..1092918 | + | 2235 | WP_000226815.1 | GTP pyrophosphokinase | - |
| ILQ41_RS05290 | 1092996..1093244 | + | 249 | WP_000581937.1 | type II toxin-antitoxin system antitoxin MazE | Antitoxin |
| ILQ41_RS05295 | 1093244..1093579 | + | 336 | WP_000254738.1 | endoribonuclease MazF | Toxin |
| ILQ41_RS05300 | 1093650..1094441 | + | 792 | WP_001071648.1 | nucleoside triphosphate pyrophosphohydrolase | - |
| ILQ41_RS05305 | 1094669..1096306 | + | 1638 | WP_000210878.1 | CTP synthase (glutamine hydrolyzing) | - |
| ILQ41_RS05310 | 1096394..1097692 | + | 1299 | WP_000036723.1 | phosphopyruvate hydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 112 a.a. Molecular weight: 12098.04 Da Isoelectric Point: 8.2618
>T176134 WP_000254738.1 NZ_CP062749:1093244-1093579 [Escherichia coli O157:H7]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG
Download Length: 336 bp
>T176134 NZ_CP082363:c2938106-2937384 [Bacillus badius]
TTGGAGAACTCTGTACTAGATATAATTAAACAAGATGAATACCGCAGTTTAGATTACTCTATAGACACAGTGGGTACCCT
TATCCATGAAGTTATAAAGCTACATAAACAGTTTTCCGAGAAATTCATCGAATTAAACGGCGCTCTCTGTTTGAATTTTA
AGAAAACATTAGTTAGAGATGTTGTGGAGCAGGTGGATGATAGTGACACTTTTGTGATTAATCAAGAGTTTCACTCCCTT
CTCAATACTTATTTGAGAAAAATCGATCAGCTGATAATTGATATCGATTTAGAATACACCTATAATAAATTCGATTTTCG
GTTAAGGGTTAAACAGCTGGAATCAATTATTTATAAGTTGTGCCATTATAACTCTGGTAAAGAAGAAAGCGGAAGATTAC
CTTTAAACAAATGTTTGAATGACCTTCTAGGTTTTCGCATTATGATGCCAGGCTTTCAACATGGATGCGAATCTTTCTCC
AAAATGTGTCAGCATATAGAGAAGTTTTATAAAATAAAGTATAGAAATTCTTCTAAAGGAGATTATAAAGCTACACACGT
ATACTTTTATGGGGGTAGTAATAAAAATTTTCCTTGGGAGTTGCAAATATGGTTACCTGAAGATTATATGGGTAATTATG
AATCACATGCCAAACATAAACAAGAATACATAAAATCTGCAAAAATACATAAGCAAGCTTTAAGAAGTCAAGGAGGTGTT
TGA
TTGGAGAACTCTGTACTAGATATAATTAAACAAGATGAATACCGCAGTTTAGATTACTCTATAGACACAGTGGGTACCCT
TATCCATGAAGTTATAAAGCTACATAAACAGTTTTCCGAGAAATTCATCGAATTAAACGGCGCTCTCTGTTTGAATTTTA
AGAAAACATTAGTTAGAGATGTTGTGGAGCAGGTGGATGATAGTGACACTTTTGTGATTAATCAAGAGTTTCACTCCCTT
CTCAATACTTATTTGAGAAAAATCGATCAGCTGATAATTGATATCGATTTAGAATACACCTATAATAAATTCGATTTTCG
GTTAAGGGTTAAACAGCTGGAATCAATTATTTATAAGTTGTGCCATTATAACTCTGGTAAAGAAGAAAGCGGAAGATTAC
CTTTAAACAAATGTTTGAATGACCTTCTAGGTTTTCGCATTATGATGCCAGGCTTTCAACATGGATGCGAATCTTTCTCC
AAAATGTGTCAGCATATAGAGAAGTTTTATAAAATAAAGTATAGAAATTCTTCTAAAGGAGATTATAAAGCTACACACGT
ATACTTTTATGGGGGTAGTAATAAAAATTTTCCTTGGGAGTTGCAAATATGGTTACCTGAAGATTATATGGGTAATTATG
AATCACATGCCAAACATAAACAAGAATACATAAAATCTGCAAAAATACATAAGCAAGCTTTAAGAAGTCAAGGAGGTGTT
TGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9355.74 Da Isoelectric Point: 4.4665
>AT176134 WP_000581937.1 NZ_CP062749:1092996-1093244 [Escherichia coli O157:H7]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW
Download Length: 249 bp
>AT176134 NZ_CP082363:c2937382-2936633 [Bacillus badius]
GTGGCTTTTCATTTTGTTGCTATAATGAGTCATTATCACAGAGGGGCTAGAATTGGATGGCATTACTCTGCACCCGACAA
ATTGGATAAAGAATTAATTAACACTTTCTTTACTAAGGTGAAAAAGAAGTGCGGAGATGTTCATTTTGGAATTCATAAAC
TGTCTACAGAATCCCTTTCATGGGATTCTGTGGTTGATAAAGATGAGTTTTTTGCTGATGTGATAGCTACTAAGGAGATG
GATACTTTTATTGATTATGTTTCAAGGGATCAAAAGTTATCAGCTCATGACGTAGCCAAGTTTTTGTTAACTATTATTCC
TTCTTCTCATTTAAAGCTTCAAAAGTTACTGTATTATTGTTATGCTGCTTTCTTAGAAAGAACGGGTGAACGTCTTTTTG
AAGAGCCGATTGTAGCTTATAAATATGGACCAGTAATTGAAAGTGTTTTCCAAGATTTTAAAATACATGGTTCTTCTATT
ATAGATTACCAAGAAGATGGGGAGTTCGTGCTCTCAACTGAGAAAAATGCAGTTACGCCGTCGTTTATTAAAATTGTTAA
CTCAGAGCATGGGATAGTGGTTATAGATTGTATTTTAGATGTCTTGAACACCTATGGAGAGTTAGATCCTTTCGAGTTAG
TTGAAAAGACTCATCAAGAAGGAGGACCTTGGCATAGGGTGTATAAGCCTGGTGAAAATTGCGTTCTTACAGACGATTTA
ATCACTCAGTATCATCAATATGCAAAGTAA
GTGGCTTTTCATTTTGTTGCTATAATGAGTCATTATCACAGAGGGGCTAGAATTGGATGGCATTACTCTGCACCCGACAA
ATTGGATAAAGAATTAATTAACACTTTCTTTACTAAGGTGAAAAAGAAGTGCGGAGATGTTCATTTTGGAATTCATAAAC
TGTCTACAGAATCCCTTTCATGGGATTCTGTGGTTGATAAAGATGAGTTTTTTGCTGATGTGATAGCTACTAAGGAGATG
GATACTTTTATTGATTATGTTTCAAGGGATCAAAAGTTATCAGCTCATGACGTAGCCAAGTTTTTGTTAACTATTATTCC
TTCTTCTCATTTAAAGCTTCAAAAGTTACTGTATTATTGTTATGCTGCTTTCTTAGAAAGAACGGGTGAACGTCTTTTTG
AAGAGCCGATTGTAGCTTATAAATATGGACCAGTAATTGAAAGTGTTTTCCAAGATTTTAAAATACATGGTTCTTCTATT
ATAGATTACCAAGAAGATGGGGAGTTCGTGCTCTCAACTGAGAAAAATGCAGTTACGCCGTCGTTTATTAAAATTGTTAA
CTCAGAGCATGGGATAGTGGTTATAGATTGTATTTTAGATGTCTTGAACACCTATGGAGAGTTAGATCCTTTCGAGTTAG
TTGAAAAGACTCATCAAGAAGGAGGACCTTGGCATAGGGTGTATAAGCCTGGTGAAAATTGCGTTCTTACAGACGATTTA
ATCACTCAGTATCATCAATATGCAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|