Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3757565..3758270 Replicon chromosome
Accession NZ_CP062744
Organism Escherichia coli O157:H7 strain Z1615

Toxin (Protein)


Gene name relE Uniprot ID Q8X3N0
Locus tag ILQ43_RS19250 Protein ID WP_000539519.1
Coordinates 3757565..3757951 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag ILQ43_RS19255 Protein ID WP_001280945.1
Coordinates 3757941..3758270 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ43_RS19230 3753569..3754195 + 627 WP_001295292.1 glutathione S-transferase GstB -
ILQ43_RS19235 3754192..3755307 - 1116 WP_000554959.1 aldose sugar dehydrogenase YliI -
ILQ43_RS19240 3755418..3755801 - 384 WP_000497137.1 biofilm formation regulator BssR -
ILQ43_RS19245 3756014..3757339 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
ILQ43_RS19250 3757565..3757951 + 387 WP_000539519.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ILQ43_RS19255 3757941..3758270 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
ILQ43_RS19260 3758340..3759668 - 1329 WP_000086905.1 GGDEF domain-containing protein -
ILQ43_RS19265 3759676..3762024 - 2349 WP_000950320.1 EAL domain-containing protein -
ILQ43_RS19270 3762202..3763113 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14279.42 Da        Isoelectric Point: 9.9296

>T176077 WP_000539519.1 NZ_CP062744:3757565-3757951 [Escherichia coli O157:H7]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGSKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T176077 NZ_CP082351:c863292-863089 [Providencia rettgeri]
ATGACCAAATCTGATTATCTGATGCGTTTAAGAAAATGCACAACAATTGAAACTCTTGAGCGTGTCATTGAAAAAAATAA
GTATGAATTATCTGATGATGAGCTAGAGCTATTCTATTCAGCTGCAGATCACCGCTTAGCTGAGCTCACAATGAATAAGC
TTTATGATAAAATTCCAGCTTCTGTTTGGAAATTTGTTAGGTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT176077 WP_001280945.1 NZ_CP062744:3757941-3758270 [Escherichia coli O157:H7]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT176077 NZ_CP082351:c863734-863366 [Providencia rettgeri]
ATGGATGAATACTCACCCAAAAGACACGATATAGCAGAACTAAAATACTTATGTAATAGCCTCAATAGAGACGCTATTTT
AAGCTTACAAAAAACAAATACACACTGGATTAATGATTTAAGCTCCCCGCAAAGCGCAGCCTTGAATGAACTTATTGAAC
ATATCGCTGCATTTGTATGGCGGTTTAAAATCAAATATCCAAAAGAAAATCTTGTTATATCACTTATCGAAGAGTATCTC
GATGAGACCTACGATTTATTCGGCAGCCCAGTCATCACGCTCAGTGAAATTATAGACTGGGAAGCAATGAATCAGAGTCT
TGTCACTGTGTTGGATGATGACCTAAAGTGTCTAACCAGCAAAACCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References