Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1780..2339 Replicon plasmid pZ1626-1
Accession NZ_CP062743
Organism Escherichia coli O157:H7 strain Z1626

Toxin (Protein)


Gene name relE Uniprot ID O82928
Locus tag ILQ44_RS27315 Protein ID WP_000421248.1
Coordinates 2064..2339 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C1J8K5
Locus tag ILQ44_RS27310 Protein ID WP_001178089.1
Coordinates 1780..2064 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ44_RS27305 13..869 + 857 Protein_1 incFII family plasmid replication initiator RepA -
ILQ44_RS27310 1780..2064 + 285 WP_001178089.1 ribbon-helix-helix domain-containing protein Antitoxin
ILQ44_RS27315 2064..2339 + 276 WP_000421248.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ILQ44_RS27320 2434..2640 + 207 WP_001105064.1 hypothetical protein -
ILQ44_RS27325 2742..2953 - 212 Protein_5 transposase -
ILQ44_RS27330 2997..3562 - 566 Protein_6 IS3 family transposase -
ILQ44_RS27335 3562..3978 - 417 Protein_7 IS91 family transposase -
ILQ44_RS27340 3978..4163 - 186 WP_001302179.1 hypothetical protein -
ILQ44_RS27345 4340..6550 + 2211 WP_000592771.1 catalase/peroxidase KatP -
ILQ44_RS27350 6594..6981 + 388 Protein_10 cytochrome b562 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - espP / espP / espP / stcE / exeE / exeF / exeG / hlyC / hlyA / hlyB / hlyD / toxB 1..92746 92746


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10735.42 Da        Isoelectric Point: 9.9324

>T176048 WP_000421248.1 NZ_CP062743:2064-2339 [Escherichia coli O157:H7]
MELKWSSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T176048 NZ_CP082347:c78983-78693 [Pantoea dispersa]
ATGACTTATAAATTAAAGTTCGTTCCTTCCGCTGAAAAGGAGTGGAAGAAACTGGGTCATCCGGTGCGTGAGCAGTTTAA
GAAAAAGCTGGTACAACGGCTGGAAAATCCCCGTGTCCCCTCAGCACAACTTCACGGACGAAAAGATCAGTACAAAATAA
AACTACGTGCTTCAGGCTATCGCCTGGTGTACCTGGTGCAGGATGAAACCATCACTGTCATGGTATTAGGTGTGGGTAAA
CGCGAAGGCAGTCAGGTCTATGCGGATACGGAATACAGATTGCCTGAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10474.89 Da        Isoelectric Point: 5.6558

>AT176048 WP_001178089.1 NZ_CP062743:1780-2064 [Escherichia coli O157:H7]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp

>AT176048 NZ_CP082347:c79227-78973 [Pantoea dispersa]
ATGCCATTTCAGATCCTGTCAAACACCGCTGCCAGCATCACCGATTTAAAGCGTGATCCCATGGGAACAGTGCGTTCAGC
GGAAGGGGAAACCATTGCTATCTTAAACCGCAACGAGCCCGCTTTTTACTGCGTTCCACCGGCTGTTTACCAATATCTGA
TGGAATTAGCAGAAGATGCAGAACTGGGTCGTATCGCTGATGAACGCATTTCTGAATTAGCGGATGCGAAAGAGATTTCG
CTGGATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z6FAZ0

Antitoxin

Source ID Structure
AlphaFold DB A0A731IHA8

References