Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3591473..3591951 Replicon chromosome
Accession NZ_CP062742
Organism Escherichia coli O157:H7 strain Z1626

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag ILQ44_RS18470 Protein ID WP_001303876.1
Coordinates 3591664..3591951 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag ILQ44_RS18465 Protein ID WP_000536233.1
Coordinates 3591473..3591664 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ44_RS18430 3586877..3587647 - 771 WP_000450992.1 DUF1627 domain-containing protein -
ILQ44_RS18435 3587669..3588415 - 747 WP_000788751.1 ATP-binding protein -
ILQ44_RS18440 3588422..3589513 - 1092 WP_001205823.1 hypothetical protein -
ILQ44_RS18445 3589592..3590047 + 456 WP_000273724.1 hypothetical protein -
ILQ44_RS18450 3590254..3590679 - 426 WP_000693855.1 Rha family transcriptional regulator -
ILQ44_RS18455 3590663..3590935 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
ILQ44_RS18460 3591044..3591445 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
ILQ44_RS18465 3591473..3591664 + 192 WP_000536233.1 hypothetical protein Antitoxin
ILQ44_RS18470 3591664..3591951 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ILQ44_RS18475 3592229..3592384 + 156 WP_000379575.1 DUF1391 family protein -
ILQ44_RS18480 3592526..3592915 + 390 WP_000394511.1 hypothetical protein -
ILQ44_RS18485 3593102..3593287 - 186 WP_001133046.1 hypothetical protein -
ILQ44_RS18490 3593861..3594049 + 189 WP_000413705.1 cell division inhibition protein DicB -
ILQ44_RS18495 3594046..3594237 + 192 WP_001098307.1 DUF1482 family protein -
ILQ44_RS18500 3594331..3596802 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T176038 WP_001303876.1 NZ_CP062742:3591664-3591951 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T176038 NZ_CP082342:532831-533202 [Pantoea dispersa]
GTGTGGCAGGTTGAAGCAACAGATCGGTTTTGGAAATGGTTGCAGGCTCAGGATGAAGCGTTGCGTCTCGACGTGCTTGC
CGCCCTGAAGCTTCTGGCGCAGGACGGTCCGCATCTTGGCCGCCCTTTCGTTGATACCCTGATGTTATCGCGGGTGCCCA
ATATGAAAGAGCTTCGCGTGCAAAGTAAAGGTCGTCCCATCCGCAGCTTTTTTGTTTTCGATCCGCGCCGCCATGCTATT
GTGCTGTGTGCCGGCAACAAACAGGGTAAAAATCAAAAGCGTTTCTATCAGCAGATGCTTCGCATTGCCGAAACCGAATA
CCATCATCATCTGAACGCAATCGGGGAAACACATAATGAAAACCTTGGATGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT176038 WP_000536233.1 NZ_CP062742:3591473-3591664 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT176038 NZ_CP082342:533186-533485 [Pantoea dispersa]
ATGAAAACCTTGGATGAGATGCTGGCGGCGCTGACGCCCGAACAGCAACATCAGGTCAATGAACGCGTCAGCCAGATGCG
TCTGGAATATCAGCTTTATCAATTACGTGAGCAGATGCAGCGGACTCAGCGTCAGCAAGCGCAGGCTATGCACATTGCCC
AGTCATCTGTGGCGGCGATGGAAGCGCGTGGCGCAGAGTTAAAGATTTCCACGCTGAAGCGCTACATTGAGGCGCTGGGT
GGAGAGCTGACGCTGGGTGTAAAGATGCCGGGTGGCCAGCATGTTGACTTAATTATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References