Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2592718..2593189 | Replicon | chromosome |
| Accession | NZ_CP062742 | ||
| Organism | Escherichia coli O157:H7 strain Z1626 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | ILQ44_RS13060 | Protein ID | WP_001303511.1 |
| Coordinates | 2592718..2592996 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | ILQ44_RS13065 | Protein ID | WP_001302048.1 |
| Coordinates | 2592998..2593189 (-) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ILQ44_RS13025 | 2587724..2587908 | - | 185 | Protein_2543 | DUF3596 domain-containing protein | - |
| ILQ44_RS13030 | 2587943..2588194 | - | 252 | WP_000005552.1 | excisionase family protein | - |
| ILQ44_RS13035 | 2588267..2590738 | - | 2472 | WP_000048458.1 | exonuclease | - |
| ILQ44_RS13040 | 2590831..2591022 | - | 192 | WP_001090200.1 | DUF1482 family protein | - |
| ILQ44_RS13045 | 2591019..2591207 | - | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| ILQ44_RS13050 | 2591776..2591994 | - | 219 | WP_001171930.1 | hypothetical protein | - |
| ILQ44_RS13055 | 2592066..2592365 | - | 300 | WP_001240334.1 | hypothetical protein | - |
| ILQ44_RS13060 | 2592718..2592996 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| ILQ44_RS13065 | 2592998..2593189 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| ILQ44_RS13070 | 2593210..2593581 | - | 372 | WP_001169686.1 | hypothetical protein | - |
| ILQ44_RS13075 | 2593679..2593981 | + | 303 | WP_000172738.1 | transcriptional regulator | - |
| ILQ44_RS13080 | 2593978..2594403 | + | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
| ILQ44_RS13085 | 2594426..2595388 | + | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| ILQ44_RS13090 | 2595395..2596135 | + | 741 | WP_000788938.1 | ATP-binding protein | - |
| ILQ44_RS13095 | 2596161..2596930 | + | 770 | Protein_2557 | DUF1627 domain-containing protein | - |
| ILQ44_RS13100 | 2596946..2597341 | + | 396 | WP_001118159.1 | DUF977 family protein | - |
| ILQ44_RS13105 | 2597398..2597982 | + | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | nleG7' / nleC | 2577838..2729755 | 151917 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T176031 WP_001303511.1 NZ_CP062742:c2592996-2592718 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T176031 NZ_CP082341:3487702-3488184 [Pantoea dispersa]
ATGGAAATAAAAGTCACTGCGCCTGCTTTACTGACAGAGGGGCATGATCTTGAGCCGTTCGATAGCGGAAATATAGTTCT
TGATGACTGGCTTCGCCGGCGTGCGTTGAAAAATCAGCATCTCAATGCCTCCCGTACATTCGTCATCTGTCTTGAAGGAA
CCATGCGGGTAGTGGGTTATTATTCCATCGCGACCGGCTCGGTAAGTCATGTCGATTTGAGTCGTAGTCTCAGACAGAAT
ATGCCCGATCCCGTACCGGTTGTTTTACTGGGCCGTCTTGCAGTCGATGTAACTACTCAGGGCAATAAATTCGGGAAATG
GTTGCTGAATGATGCCGTGATACGCGTTTCAAATCTGGCGGATCAAGTCGGCATTAAGGCTATCATGGTACATGCAATTG
ACGAGCAGGCTAAAGCGTTCTACGACTACTTTGGCTTTGTCCAGTCCCCGGTTGCCGCTAACACATTATTCTACAAAATA
TGA
ATGGAAATAAAAGTCACTGCGCCTGCTTTACTGACAGAGGGGCATGATCTTGAGCCGTTCGATAGCGGAAATATAGTTCT
TGATGACTGGCTTCGCCGGCGTGCGTTGAAAAATCAGCATCTCAATGCCTCCCGTACATTCGTCATCTGTCTTGAAGGAA
CCATGCGGGTAGTGGGTTATTATTCCATCGCGACCGGCTCGGTAAGTCATGTCGATTTGAGTCGTAGTCTCAGACAGAAT
ATGCCCGATCCCGTACCGGTTGTTTTACTGGGCCGTCTTGCAGTCGATGTAACTACTCAGGGCAATAAATTCGGGAAATG
GTTGCTGAATGATGCCGTGATACGCGTTTCAAATCTGGCGGATCAAGTCGGCATTAAGGCTATCATGGTACATGCAATTG
ACGAGCAGGCTAAAGCGTTCTACGACTACTTTGGCTTTGTCCAGTCCCCGGTTGCCGCTAACACATTATTCTACAAAATA
TGA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT176031 WP_001302048.1 NZ_CP062742:c2593189-2592998 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT176031 NZ_CP082341:3487427-3487711 [Pantoea dispersa]
ATGCAAACAACTTTCCGTAAATCCGTTCGTGATAAGCAAATCAATATCCGTGCCACGGATGAAGAGCGCGCAGTGATTGA
TTATGCTGCGAGTCTGGTGAATAAAAACCGTACTGATTTCATCATTGAAAGGGCTGTGCATGAGGCACAGAACATTATTC
TGGACCAACGCGTGTTCATTCTTGATGACGAACGTTATCAGGAGTTCATCAGGCAACTCGAAGCCCCTGTACAAAATGTT
GAAGGTCGTCAGCGACTGATGGATGTAAAACCTGAATGGAAATAA
ATGCAAACAACTTTCCGTAAATCCGTTCGTGATAAGCAAATCAATATCCGTGCCACGGATGAAGAGCGCGCAGTGATTGA
TTATGCTGCGAGTCTGGTGAATAAAAACCGTACTGATTTCATCATTGAAAGGGCTGTGCATGAGGCACAGAACATTATTC
TGGACCAACGCGTGTTCATTCTTGATGACGAACGTTATCAGGAGTTCATCAGGCAACTCGAAGCCCCTGTACAAAATGTT
GAAGGTCGTCAGCGACTGATGGATGTAAAACCTGAATGGAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|