Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3792848..3793326 Replicon chromosome
Accession NZ_CP062739
Organism Escherichia coli O157:H7 strain Z1723

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag ILQ45_RS19650 Protein ID WP_001303876.1
Coordinates 3793039..3793326 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag ILQ45_RS19645 Protein ID WP_000536233.1
Coordinates 3792848..3793039 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ45_RS19610 3788252..3789022 - 771 WP_000450992.1 DUF1627 domain-containing protein -
ILQ45_RS19615 3789044..3789790 - 747 WP_000788751.1 ATP-binding protein -
ILQ45_RS19620 3789797..3790888 - 1092 WP_001205823.1 hypothetical protein -
ILQ45_RS19625 3790967..3791422 + 456 WP_000273724.1 hypothetical protein -
ILQ45_RS19630 3791629..3792054 - 426 WP_000693855.1 Rha family transcriptional regulator -
ILQ45_RS19635 3792038..3792310 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
ILQ45_RS19640 3792419..3792820 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
ILQ45_RS19645 3792848..3793039 + 192 WP_000536233.1 hypothetical protein Antitoxin
ILQ45_RS19650 3793039..3793326 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ILQ45_RS19655 3793604..3793759 + 156 WP_000379575.1 DUF1391 family protein -
ILQ45_RS19660 3793901..3794290 + 390 WP_000394511.1 hypothetical protein -
ILQ45_RS19665 3794477..3794662 - 186 WP_001133046.1 hypothetical protein -
ILQ45_RS19670 3795236..3795424 + 189 WP_000413705.1 cell division inhibition protein DicB -
ILQ45_RS19675 3795421..3795612 + 192 WP_001098307.1 DUF1482 family protein -
ILQ45_RS19680 3795706..3798177 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T176002 WP_001303876.1 NZ_CP062739:3793039-3793326 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T176002 NZ_CP082327:1903308-1903411 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT176002 WP_000536233.1 NZ_CP062739:3792848-3793039 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT176002 NZ_CP082327:c1903449-1903178 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References