Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3579628..3580106 Replicon chromosome
Accession NZ_CP062736
Organism Escherichia coli O157:H7 strain Z1766

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag ILQ46_RS18410 Protein ID WP_001303876.1
Coordinates 3579819..3580106 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag ILQ46_RS18405 Protein ID WP_000536233.1
Coordinates 3579628..3579819 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ46_RS18370 3575032..3575802 - 771 WP_000450992.1 DUF1627 domain-containing protein -
ILQ46_RS18375 3575824..3576570 - 747 WP_000788751.1 ATP-binding protein -
ILQ46_RS18380 3576577..3577668 - 1092 WP_001205823.1 hypothetical protein -
ILQ46_RS18385 3577747..3578202 + 456 WP_000273724.1 hypothetical protein -
ILQ46_RS18390 3578409..3578834 - 426 WP_000693855.1 Rha family transcriptional regulator -
ILQ46_RS18395 3578818..3579090 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
ILQ46_RS18400 3579199..3579600 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
ILQ46_RS18405 3579628..3579819 + 192 WP_000536233.1 hypothetical protein Antitoxin
ILQ46_RS18410 3579819..3580106 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ILQ46_RS18415 3580384..3580539 + 156 WP_000379575.1 DUF1391 family protein -
ILQ46_RS18420 3580681..3581070 + 390 WP_000394511.1 hypothetical protein -
ILQ46_RS18425 3581257..3581442 - 186 WP_001133046.1 hypothetical protein -
ILQ46_RS18430 3582016..3582204 + 189 WP_000413705.1 cell division inhibition protein DicB -
ILQ46_RS18435 3582201..3582392 + 192 WP_001098307.1 DUF1482 family protein -
ILQ46_RS18440 3582486..3584957 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T175964 WP_001303876.1 NZ_CP062736:3579819-3580106 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T175964 NZ_CP082293:c82816-82400 [Pantoea agglomerans]
GTGAACACAACCTATATGCTGGATACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTACTGAAGCGCCT
GGAGCAGGCAGTGATGCGCGGCCACCGCATCGTGGTGTCGGCCATCACCTACTCAGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGACACGCACAGCTGGTTGACGCGTTCTGCGCCCGGCTCGATGCCGTCCTGCCCTGGGATCGCGCC
GCGGTGGATGCCACCACGGAGATTAAAGTGGCGCTGCGCCAGGCCGGGACATCGATCGGCCCGAACGATACGGCGATTGC
CGGGCACGCCATCTCGGCTGGCGCCGTGCTGGTGACGAACAATACGCGGGAATTTGCGCGTGTTCCGGATCTGGCTCTGG
AAGACTGGGTATATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT175964 WP_000536233.1 NZ_CP062736:3579628-3579819 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT175964 NZ_CP082293:c83043-82813 [Pantoea agglomerans]
ATGAGAACCGTATCCATTTTTAAAAACGGCAACAATCGCGCCATTCGTCTTCCTCGTGACATGGATTTTGAAGGAGTGAG
CGAACTCGAAATCATCCGGGAAGGGGACAGCATCATCCTGCGTCCCGCCCGGCCGACCTGGGGCTCATACCTTGAACTCG
AAAAGGCCGATCCGGACTTTATGGCAGAGCGCGAAGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References