Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/UPF0150(antitoxin) |
Location | 2852069..2852707 | Replicon | chromosome |
Accession | NZ_CP062736 | ||
Organism | Escherichia coli O157:H7 strain Z1766 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | S1F9G9 |
Locus tag | ILQ46_RS14485 | Protein ID | WP_000813794.1 |
Coordinates | 2852531..2852707 (-) | Length | 59 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | - |
Locus tag | ILQ46_RS14480 | Protein ID | WP_001270286.1 |
Coordinates | 2852069..2852485 (-) | Length | 139 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ILQ46_RS14460 | 2847221..2848162 | - | 942 | WP_001251315.1 | ABC transporter permease | - |
ILQ46_RS14465 | 2848163..2849176 | - | 1014 | WP_000220402.1 | ABC transporter ATP-binding protein | - |
ILQ46_RS14470 | 2849194..2850339 | - | 1146 | WP_000047432.1 | ABC transporter substrate-binding protein | - |
ILQ46_RS14475 | 2850584..2851990 | - | 1407 | WP_000760654.1 | PLP-dependent aminotransferase family protein | - |
ILQ46_RS14480 | 2852069..2852485 | - | 417 | WP_001270286.1 | type II toxin-antitoxin system antitoxin HicB | Antitoxin |
ILQ46_RS14485 | 2852531..2852707 | - | 177 | WP_000813794.1 | type II toxin-antitoxin system mRNA interferase toxin HicA | Toxin |
ILQ46_RS14490 | 2852929..2853159 | + | 231 | WP_000494244.1 | YncJ family protein | - |
ILQ46_RS14495 | 2853251..2855212 | - | 1962 | WP_001303492.1 | 23S rRNA 5-hydroxycytidine C2501 synthase | - |
ILQ46_RS14500 | 2855285..2855821 | - | 537 | WP_000429145.1 | DNA-binding transcriptional regulator SutR | - |
ILQ46_RS14505 | 2855874..2857085 | + | 1212 | WP_071525382.1 | BenE family transporter YdcO | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6749.83 Da Isoelectric Point: 11.2298
>T175959 WP_000813794.1 NZ_CP062736:c2852707-2852531 [Escherichia coli O157:H7]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS
Download Length: 177 bp
>T175959 NZ_CP082292:1531534-1531887 [Pantoea agglomerans]
GTGTGGATGATTAAAACGACAGAGCGGTTTGATCGCTGGTTTACGTTGCTTAATGACAGCGATCGCGCCTGCGTGCTGGC
TGCATTGATGGTGCTGCGGGAAAAGGGGCCGGGATTAAGCCGACCCTATGCGGATACGATTAAAGGTTCCGCTTATATCA
ACATGAAAGAGTTACGTATCCAGAGCCGCGGCGACCCAATAAGGGCTTTCTATGCTTTTGACCCGAACCGCACGGCAATT
GTGCTGTGTGCCGGTAATAAGGCGGGCAATGAAAAGCGATTTTATCGGGAGATGCTTCCGGTTGCCGATCGGGAATTCAC
ACACTGGCTAAAAAGCTTTAACCATAAGGAGTAA
GTGTGGATGATTAAAACGACAGAGCGGTTTGATCGCTGGTTTACGTTGCTTAATGACAGCGATCGCGCCTGCGTGCTGGC
TGCATTGATGGTGCTGCGGGAAAAGGGGCCGGGATTAAGCCGACCCTATGCGGATACGATTAAAGGTTCCGCTTATATCA
ACATGAAAGAGTTACGTATCCAGAGCCGCGGCGACCCAATAAGGGCTTTCTATGCTTTTGACCCGAACCGCACGGCAATT
GTGCTGTGTGCCGGTAATAAGGCGGGCAATGAAAAGCGATTTTATCGGGAGATGCTTCCGGTTGCCGATCGGGAATTCAC
ACACTGGCTAAAAAGCTTTAACCATAAGGAGTAA
Antitoxin
Download Length: 139 a.a. Molecular weight: 15246.63 Da Isoelectric Point: 4.7386
>AT175959 WP_001270286.1 NZ_CP062736:c2852485-2852069 [Escherichia coli O157:H7]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV
Download Length: 417 bp
>AT175959 NZ_CP082292:1531892-1532194 [Pantoea agglomerans]
ATGGGCAGAACGCTGGAACAGCTTATTGCGGATGAAAAACCGGAAGTCGTTGCCGACGCACAGGCTATGGCGACCGAAAT
CCTGCTCAACATTCACCTTGCCGAGCTGCGTGAGAAAGTGCAGAAAACGCAAGTGGAAATGGCGCAGGCGCTGGGCATCA
CACAGCCGACCGTGGCGGGCATGGAAAAGCCGGGGCGTGACCTGAAGCTTTCCACGCTCAAACGCTACGTCGATGCGGCA
GGGGGGAAACTGCGGCTGGTGGTGGAACTGCCGGATGGTTCCCACTACGGGTTCGTGGTGTAA
ATGGGCAGAACGCTGGAACAGCTTATTGCGGATGAAAAACCGGAAGTCGTTGCCGACGCACAGGCTATGGCGACCGAAAT
CCTGCTCAACATTCACCTTGCCGAGCTGCGTGAGAAAGTGCAGAAAACGCAAGTGGAAATGGCGCAGGCGCTGGGCATCA
CACAGCCGACCGTGGCGGGCATGGAAAAGCCGGGGCGTGACCTGAAGCTTTCCACGCTCAAACGCTACGTCGATGCGGCA
GGGGGGAAACTGCGGCTGGTGGTGGAACTGCCGGATGGTTCCCACTACGGGTTCGTGGTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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