Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | cptAB/Cpta(toxin) |
| Location | 946220..946874 | Replicon | chromosome |
| Accession | NZ_CP062733 | ||
| Organism | Escherichia coli O157:H7 strain Z1767 | ||
Toxin (Protein)
| Gene name | cptA | Uniprot ID | S1PAM6 |
| Locus tag | ILQ47_RS04630 | Protein ID | WP_000244781.1 |
| Coordinates | 946467..946874 (+) | Length | 136 a.a. |
Antitoxin (Protein)
| Gene name | cptB | Uniprot ID | S1PPB1 |
| Locus tag | ILQ47_RS04625 | Protein ID | WP_000354046.1 |
| Coordinates | 946220..946486 (+) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ILQ47_RS04605 | 942308..943741 | - | 1434 | WP_001310226.1 | 6-phospho-beta-glucosidase BglA | - |
| ILQ47_RS04610 | 943786..944097 | + | 312 | WP_001182957.1 | N(4)-acetylcytidine aminohydrolase | - |
| ILQ47_RS04615 | 944261..944920 | + | 660 | WP_000250274.1 | hemolysin III family protein | - |
| ILQ47_RS04620 | 944997..945977 | - | 981 | WP_000886053.1 | tRNA-modifying protein YgfZ | - |
| ILQ47_RS04625 | 946220..946486 | + | 267 | WP_000354046.1 | FAD assembly factor SdhE | Antitoxin |
| ILQ47_RS04630 | 946467..946874 | + | 408 | WP_000244781.1 | protein YgfX | Toxin |
| ILQ47_RS04635 | 946914..947435 | - | 522 | WP_001055874.1 | flavodoxin FldB | - |
| ILQ47_RS04640 | 947547..948443 | + | 897 | WP_000806638.1 | site-specific tyrosine recombinase XerD | - |
| ILQ47_RS04645 | 948468..949178 | + | 711 | WP_000715214.1 | bifunctional protein-disulfide isomerase/oxidoreductase DsbC | - |
| ILQ47_RS04650 | 949184..950917 | + | 1734 | WP_000813185.1 | single-stranded-DNA-specific exonuclease RecJ | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 136 a.a. Molecular weight: 16061.99 Da Isoelectric Point: 11.5202
>T175909 WP_000244781.1 NZ_CP062733:946467-946874 [Escherichia coli O157:H7]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR
Download Length: 408 bp
>T175909 NZ_CP082244:1719710-1720279 [Pseudomonas otitidis]
ATGTTCAATCCGCAACCGGTCACCCTGCAGCGTGGCGCATTGCGCCTGGAGCCACTGGGGGAGGCCGATGTCAGCGAGCT
GGCGGCCCTGGCCGAAGCCAATCGCAACGAACTGGTCTACATGAGCGGCCCGCTGCGGCCGGACTGGTACCGCCAGGGCA
TCGCCCAGCAGCGCGAAGGCCAGGCCGTGGTGTTCGCCATCCGCCTGGGTGACCGCCTGGTGGGCACCAGCCGATTCGCC
GAATTCATGCCGGCCCTGCCTGCCGTGGAGATCGGCTGGACCTGGCTGGCCGGCAGCGAGCACGGCACCGGCCTCAACGC
CTCGATCAAGTACCTGATGCTGCGCCACGCCTTCGAGGAGTGGCAGGTGGTGCGGGTGCAGCTGAAGACCGCCGGCAGCA
ACCTGCGCTCGCAACGGGCCATCGAGAAGCTCGGCGCGGTGCGTGAGGGGGTGCTGCGCAACCACCGTCGCCTGGCCGAC
GGGCGCCTGGACGACAGCGTCATGTTCAGCATCACCGACCACGAGTGGCCGGCGGTGAAGCAGGCCCTGGAAGCCGCATT
CGTCCAATGA
ATGTTCAATCCGCAACCGGTCACCCTGCAGCGTGGCGCATTGCGCCTGGAGCCACTGGGGGAGGCCGATGTCAGCGAGCT
GGCGGCCCTGGCCGAAGCCAATCGCAACGAACTGGTCTACATGAGCGGCCCGCTGCGGCCGGACTGGTACCGCCAGGGCA
TCGCCCAGCAGCGCGAAGGCCAGGCCGTGGTGTTCGCCATCCGCCTGGGTGACCGCCTGGTGGGCACCAGCCGATTCGCC
GAATTCATGCCGGCCCTGCCTGCCGTGGAGATCGGCTGGACCTGGCTGGCCGGCAGCGAGCACGGCACCGGCCTCAACGC
CTCGATCAAGTACCTGATGCTGCGCCACGCCTTCGAGGAGTGGCAGGTGGTGCGGGTGCAGCTGAAGACCGCCGGCAGCA
ACCTGCGCTCGCAACGGGCCATCGAGAAGCTCGGCGCGGTGCGTGAGGGGGTGCTGCGCAACCACCGTCGCCTGGCCGAC
GGGCGCCTGGACGACAGCGTCATGTTCAGCATCACCGACCACGAGTGGCCGGCGGTGAAGCAGGCCCTGGAAGCCGCATT
CGTCCAATGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10547.12 Da Isoelectric Point: 5.1599
>AT175909 WP_000354046.1 NZ_CP062733:946220-946486 [Escherichia coli O157:H7]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI
Download Length: 267 bp
>AT175909 NZ_CP082244:1720276-1721118 [Pseudomonas otitidis]
ATGAGCACGGGGGGTGAGCGCACGCGCTTCTGGCAGGCCAGTGCGCTGAGCGGGGTCGAGCTCCTGCATGCGCGCTACAT
CCAGCATCGCTTCTCGCCCCACGTGCACGAAGGCTACGTCTTCACCATCCTCGAGTCCGGCGCCCAGCGCTTCCGCCACC
GCGGCAGCGACCACCTGGCCGCCGTCGGCAGCATGGTGCTGATCAACCCGGACGAGCTGCACACCGGCTCCAAGGCCCAC
GAGGAAGGCTGGCGCTACCGGGGGTTCTACCCCGACCTGCACCGGGTGACCGATGTGCTGGACGAACTGGAGATCGCCAC
CGGCGGCCTGCCCACCTTCGCCGACAGCGTGCTGCATGACCCCGAGGTGACCCGCCGCTTCCTCGACCTGCACTGCCTGC
TGGAGCGCAATGCCTCCGCCCTGGAGCAGCAGGTGGCCTGGCGCGAGGCGATCCTGCTGCTGTTCAGCCGCCACGCGCGC
ATCGGTGCGCCACGGCCGGCGGGGCAGGAGCCCCAGGCCGTGGCGCTGGCCCGCGAGGTGCTGGCGGCGCGCCTGGCCTC
GCCGCCATCCCTGGAGGAACTGGCGGCCCTGGTGGGGCTTTCGCCGTTCCACTTCGCCCGGGTCTTCCAGCGCGCAACCG
GGATGCCGCCCCACGCGTGGCTCAAGCAGCGTCGCCTGGAGCAGGCGCGGGCCATGCTGCGCAGCGGTTGCGCGCCGTTG
TCGGTGGCGATGCAGCTGGGCTTTGCCGACCAGAGCCACCTGACCCGTCAGTTCAAGCAGACCTACGGGGTAGGTCCCGG
CGAATACCGGACCGCCAGCGCAAGATCATTCAAGACCGACTGA
ATGAGCACGGGGGGTGAGCGCACGCGCTTCTGGCAGGCCAGTGCGCTGAGCGGGGTCGAGCTCCTGCATGCGCGCTACAT
CCAGCATCGCTTCTCGCCCCACGTGCACGAAGGCTACGTCTTCACCATCCTCGAGTCCGGCGCCCAGCGCTTCCGCCACC
GCGGCAGCGACCACCTGGCCGCCGTCGGCAGCATGGTGCTGATCAACCCGGACGAGCTGCACACCGGCTCCAAGGCCCAC
GAGGAAGGCTGGCGCTACCGGGGGTTCTACCCCGACCTGCACCGGGTGACCGATGTGCTGGACGAACTGGAGATCGCCAC
CGGCGGCCTGCCCACCTTCGCCGACAGCGTGCTGCATGACCCCGAGGTGACCCGCCGCTTCCTCGACCTGCACTGCCTGC
TGGAGCGCAATGCCTCCGCCCTGGAGCAGCAGGTGGCCTGGCGCGAGGCGATCCTGCTGCTGTTCAGCCGCCACGCGCGC
ATCGGTGCGCCACGGCCGGCGGGGCAGGAGCCCCAGGCCGTGGCGCTGGCCCGCGAGGTGCTGGCGGCGCGCCTGGCCTC
GCCGCCATCCCTGGAGGAACTGGCGGCCCTGGTGGGGCTTTCGCCGTTCCACTTCGCCCGGGTCTTCCAGCGCGCAACCG
GGATGCCGCCCCACGCGTGGCTCAAGCAGCGTCGCCTGGAGCAGGCGCGGGCCATGCTGCGCAGCGGTTGCGCGCCGTTG
TCGGTGGCGATGCAGCTGGGCTTTGCCGACCAGAGCCACCTGACCCGTCAGTTCAAGCAGACCTACGGGGTAGGTCCCGG
CGAATACCGGACCGCCAGCGCAAGATCATTCAAGACCGACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|