Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3579627..3580105 Replicon chromosome
Accession NZ_CP062731
Organism Escherichia coli O157:H7 strain Z1768

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag ILQ48_RS18405 Protein ID WP_001303876.1
Coordinates 3579818..3580105 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag ILQ48_RS18400 Protein ID WP_000536233.1
Coordinates 3579627..3579818 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ48_RS18365 3575031..3575801 - 771 WP_000450992.1 DUF1627 domain-containing protein -
ILQ48_RS18370 3575823..3576569 - 747 WP_000788751.1 ATP-binding protein -
ILQ48_RS18375 3576576..3577667 - 1092 WP_001205823.1 hypothetical protein -
ILQ48_RS18380 3577746..3578201 + 456 WP_000273724.1 hypothetical protein -
ILQ48_RS18385 3578408..3578833 - 426 WP_000693855.1 Rha family transcriptional regulator -
ILQ48_RS18390 3578817..3579089 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
ILQ48_RS18395 3579198..3579599 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
ILQ48_RS18400 3579627..3579818 + 192 WP_000536233.1 hypothetical protein Antitoxin
ILQ48_RS18405 3579818..3580105 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ILQ48_RS18410 3580383..3580538 + 156 WP_000379575.1 DUF1391 family protein -
ILQ48_RS18415 3580680..3581069 + 390 WP_000394511.1 hypothetical protein -
ILQ48_RS18420 3581256..3581441 - 186 WP_001133046.1 hypothetical protein -
ILQ48_RS18425 3582015..3582203 + 189 WP_000413705.1 cell division inhibition protein DicB -
ILQ48_RS18430 3582200..3582391 + 192 WP_001098307.1 DUF1482 family protein -
ILQ48_RS18435 3582485..3584956 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T175890 WP_001303876.1 NZ_CP062731:3579818-3580105 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T175890 NZ_CP082237:786774-787124 [Caldalkalibacillus thermarum TA2.A1]
TTGATCGTTAAACGTGGCGATGTTTTTTTTGCGGATCTGTCACCTGTTGTAGGGTCAGAACAGGGTGGCGTACGCCCCGT
ACTTGTGATTCAAAACGATATTGGCAACCGCTTCAGCCCCACTGTTATTGTGGCAGCTATTACAGCCCAAATTCAAAAAG
CCAAACTGCCCACACACGTTGAAATTAATGCCAAGATGTATGGGTTTGAAAAAGATTCTGTCATTCTGCTCGAGCAAATA
CGCACCATTGATAAACAGCGCCTGACAGATAAGATTACCCATCTTGATGAGGAGATGATGGCACGAGTGGATGATGCCTT
GCAGATCAGCTTAGGGTTAATCGATTTTTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT175890 WP_000536233.1 NZ_CP062731:3579627-3579818 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT175890 NZ_CP082237:786492-786770 [Caldalkalibacillus thermarum TA2.A1]
GTGTCTAATTCCAAAACAAAGCGAATCATGATTACCCTTCCCCAAAACTTGCTTAAAGAAGTGGACGGGGTGGCGAAGAA
GGAGCAGTCCAACCGGAGTGAATTGATTCGCCAAGCAATGAAATTTTACTTGCGGGAACGTAAGAAACGTCAGCTGCGGG
AAAGCATGAAAAAAGGATATATGGAAATGGCCAACATAAATCTAAACATGGCATCGGAAGCGTTTCTTGCTGAGGAAGAG
GCAGATCACACCTTAGACCGCTTAGTAAGCGGGGTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References