Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3577000..3577478 Replicon chromosome
Accession NZ_CP062729
Organism Escherichia coli O157:H7 strain Z1811

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag ILQ50_RS18395 Protein ID WP_001303876.1
Coordinates 3577191..3577478 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag ILQ50_RS18390 Protein ID WP_000536233.1
Coordinates 3577000..3577191 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ50_RS18355 3572404..3573174 - 771 WP_000450992.1 DUF1627 domain-containing protein -
ILQ50_RS18360 3573196..3573942 - 747 WP_000788751.1 ATP-binding protein -
ILQ50_RS18365 3573949..3575040 - 1092 WP_001205823.1 hypothetical protein -
ILQ50_RS18370 3575119..3575574 + 456 WP_000273724.1 hypothetical protein -
ILQ50_RS18375 3575781..3576206 - 426 WP_000693855.1 Rha family transcriptional regulator -
ILQ50_RS18380 3576190..3576462 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
ILQ50_RS18385 3576571..3576972 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
ILQ50_RS18390 3577000..3577191 + 192 WP_000536233.1 hypothetical protein Antitoxin
ILQ50_RS18395 3577191..3577478 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ILQ50_RS18400 3577756..3577911 + 156 WP_000379575.1 DUF1391 family protein -
ILQ50_RS18405 3578053..3578442 + 390 WP_000394511.1 hypothetical protein -
ILQ50_RS18410 3578629..3578814 - 186 WP_001133046.1 hypothetical protein -
ILQ50_RS18415 3579388..3579576 + 189 WP_000413705.1 cell division inhibition protein DicB -
ILQ50_RS18420 3579573..3579764 + 192 WP_001098307.1 DUF1482 family protein -
ILQ50_RS18425 3579858..3582329 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T175854 WP_001303876.1 NZ_CP062729:3577191-3577478 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T175854 NZ_CP082217:c2223951-2223637 [Xanthomonas cucurbitae]
ATGGAAGTCAAATTCAGCCGCTACGATACGGCGGACTATCTCAAGACCGAGGACGATATTGCGGCCTATCTCGATGCCGT
GATGGAGGACGGTGACCCCGCACTGATCGCGGCGGCGCTCGGAGACGTGGCCCGTGCCCGCAACCTTAGCCAGCTTGCCC
GCGACGTAGGAATGAGCCGCCAAGGGCTGGACAAGGCCCTTTCAGGCGATGGCAATCCGAGCCTCGCAACCGTTGTGAAA
GTCGCTCAGGCGCTTGGCCTGCGGCTCACTTTCAAACCAACCCACGGCGGCCCCGCACCGGCCGCAGGAGCCTAG

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT175854 WP_000536233.1 NZ_CP062729:3577000-3577191 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT175854 NZ_CP082217:c2224253-2223957 [Xanthomonas cucurbitae]
ATGATCGAGCTAATAAAAACCGACCTATTCGACCGCTGGCTTGTCGGCCTTCGTGATCGTCAGGCCCGTGCGAGGATCGA
GGCGCGCATTCGGCGCTTGAGCCTTGGCAACCCCGGCGACGTGAAGCCGGTAGGCGAAGGCTTGTCGGAAATGCGGATCG
ACCACGGCCCCGGCTATCGCGTCTATTTCATGCGGCGCGGCCCCTTGGTGGTGCTGCTGCTTTGTGGAGGCGACAAGAGC
AGTCAGGAGCGGGACATTGCCCTAGCCAAGACCATTGCAGCGCAGTGGAAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References