Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3588576..3589054 Replicon chromosome
Accession NZ_CP062727
Organism Escherichia coli O157:H7 strain Z1812

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag ILQ51_RS18450 Protein ID WP_001303876.1
Coordinates 3588767..3589054 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag ILQ51_RS18445 Protein ID WP_000536233.1
Coordinates 3588576..3588767 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ51_RS18410 3583980..3584750 - 771 WP_000450992.1 DUF1627 domain-containing protein -
ILQ51_RS18415 3584772..3585518 - 747 WP_000788751.1 ATP-binding protein -
ILQ51_RS18420 3585525..3586616 - 1092 WP_001205823.1 hypothetical protein -
ILQ51_RS18425 3586695..3587150 + 456 WP_000273724.1 hypothetical protein -
ILQ51_RS18430 3587357..3587782 - 426 WP_000693855.1 Rha family transcriptional regulator -
ILQ51_RS18435 3587766..3588038 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
ILQ51_RS18440 3588147..3588548 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
ILQ51_RS18445 3588576..3588767 + 192 WP_000536233.1 hypothetical protein Antitoxin
ILQ51_RS18450 3588767..3589054 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ILQ51_RS18455 3589332..3589487 + 156 WP_000379575.1 DUF1391 family protein -
ILQ51_RS18460 3589629..3590018 + 390 WP_000394511.1 hypothetical protein -
ILQ51_RS18465 3590205..3590390 - 186 WP_001133046.1 hypothetical protein -
ILQ51_RS18470 3590964..3591152 + 189 WP_000413705.1 cell division inhibition protein DicB -
ILQ51_RS18475 3591149..3591340 + 192 WP_001098307.1 DUF1482 family protein -
ILQ51_RS18480 3591434..3593905 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T175818 WP_001303876.1 NZ_CP062727:3588767-3589054 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T175818 NZ_CP082211:c4797699-4797415 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT175818 WP_000536233.1 NZ_CP062727:3588576-3588767 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT175818 NZ_CP082211:c4797931-4797689 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References