Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2848097..2848735 Replicon chromosome
Accession NZ_CP062727
Organism Escherichia coli O157:H7 strain Z1812

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag ILQ51_RS14470 Protein ID WP_000813794.1
Coordinates 2848559..2848735 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag ILQ51_RS14465 Protein ID WP_001270286.1
Coordinates 2848097..2848513 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ51_RS14445 2843249..2844190 - 942 WP_206340605.1 ABC transporter permease subunit -
ILQ51_RS14450 2844191..2845204 - 1014 WP_000220402.1 ABC transporter ATP-binding protein -
ILQ51_RS14455 2845222..2846367 - 1146 WP_000047432.1 ABC transporter substrate-binding protein -
ILQ51_RS14460 2846612..2848018 - 1407 WP_000760654.1 PLP-dependent aminotransferase family protein -
ILQ51_RS14465 2848097..2848513 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
ILQ51_RS14470 2848559..2848735 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
ILQ51_RS14475 2848957..2849187 + 231 WP_000494244.1 YncJ family protein -
ILQ51_RS14480 2849279..2851240 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
ILQ51_RS14485 2851313..2851849 - 537 WP_000429145.1 DNA-binding transcriptional regulator SutR -
ILQ51_RS14490 2851902..2853113 + 1212 WP_071525382.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T175814 WP_000813794.1 NZ_CP062727:c2848735-2848559 [Escherichia coli O157:H7]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T175814 NZ_CP082211:c3911389-3911072 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT175814 WP_001270286.1 NZ_CP062727:c2848513-2848097 [Escherichia coli O157:H7]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT175814 NZ_CP082211:c3911079-3910792 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACAGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References