Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2590041..2590512 | Replicon | chromosome |
| Accession | NZ_CP062727 | ||
| Organism | Escherichia coli O157:H7 strain Z1812 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | ILQ51_RS13040 | Protein ID | WP_001303511.1 |
| Coordinates | 2590041..2590319 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | ILQ51_RS13045 | Protein ID | WP_001302048.1 |
| Coordinates | 2590321..2590512 (-) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ILQ51_RS13005 | 2585047..2585231 | - | 185 | Protein_2539 | DUF3596 domain-containing protein | - |
| ILQ51_RS13010 | 2585266..2585517 | - | 252 | WP_000005552.1 | excisionase family protein | - |
| ILQ51_RS13015 | 2585590..2588061 | - | 2472 | WP_000048458.1 | exonuclease | - |
| ILQ51_RS13020 | 2588154..2588345 | - | 192 | WP_001090200.1 | DUF1482 family protein | - |
| ILQ51_RS13025 | 2588342..2588530 | - | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| ILQ51_RS13030 | 2589099..2589317 | - | 219 | WP_001171930.1 | hypothetical protein | - |
| ILQ51_RS13035 | 2589389..2589688 | - | 300 | WP_001240334.1 | hypothetical protein | - |
| ILQ51_RS13040 | 2590041..2590319 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| ILQ51_RS13045 | 2590321..2590512 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| ILQ51_RS13050 | 2590533..2590904 | - | 372 | WP_001169686.1 | hypothetical protein | - |
| ILQ51_RS13055 | 2591002..2591304 | + | 303 | WP_000172738.1 | transcriptional regulator | - |
| ILQ51_RS13060 | 2591301..2591726 | + | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
| ILQ51_RS13065 | 2591749..2592711 | + | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| ILQ51_RS13070 | 2592718..2593458 | + | 741 | WP_000788938.1 | ATP-binding protein | - |
| ILQ51_RS13075 | 2593484..2594253 | + | 770 | Protein_2553 | DUF1627 domain-containing protein | - |
| ILQ51_RS13080 | 2594269..2594664 | + | 396 | WP_001118159.1 | DUF977 family protein | - |
| ILQ51_RS13085 | 2594721..2595305 | + | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | nleG7' / nleC | 2575161..2725057 | 149896 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T175811 WP_001303511.1 NZ_CP062727:c2590319-2590041 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T175811 NZ_CP082211:855724-856134 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAAATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAAATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT175811 WP_001302048.1 NZ_CP062727:c2590512-2590321 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT175811 NZ_CP082211:855477-855743 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|