Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4962318..4962913 Replicon chromosome
Accession NZ_CP062723
Organism Escherichia coli O157:H7 strain Z1814

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag ILQ53_RS24710 Protein ID WP_000239579.1
Coordinates 4962318..4962668 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID Q8XCF3
Locus tag ILQ53_RS24715 Protein ID WP_001223210.1
Coordinates 4962662..4962913 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ53_RS24690 4957764..4958786 - 1023 WP_001301928.1 ABC transporter permease -
ILQ53_RS24695 4958800..4960302 - 1503 WP_000205806.1 sugar ABC transporter ATP-binding protein -
ILQ53_RS24700 4960442..4961398 - 957 WP_000265942.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
ILQ53_RS24705 4961708..4962238 + 531 WP_000055075.1 inorganic diphosphatase -
ILQ53_RS24710 4962318..4962668 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
ILQ53_RS24715 4962662..4962913 - 252 WP_001223210.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
ILQ53_RS24720 4963125..4963466 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
ILQ53_RS24725 4963469..4967248 - 3780 WP_000060930.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T175754 WP_000239579.1 NZ_CP062723:c4962668-4962318 [Escherichia coli O157:H7]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T175754 NZ_CP082178:3421458-3422108 [Xanthomonas fragariae]
ATGTCTAGGCGCTATCCCAACCTCAACCCAGACAAAGCCCTGATCTGGCGCATCGTCCATCGCGACAACCTGCCTTGGAT
TATGGACAACGGCCTGCACTGCGGTAATGGCGGGGTGCAGAGCCCAGGCTGGGTGAGCATCGGCAATCCGGAATTGATCG
CCAAACGCGCCAATCATCCTGTGCCGCTCGCACCGGGTGGCTTCCTGAACGATTACGTGCCTTTCTACTTCACTCCATTT
TCGCCGATGCTGCGCAACATCCATACCGGCTGGGGAGGTATCCAACGACGGTCGAACGAGGAGATTGTGATACTTGTTTC
TAGCCTGCATCATGTCGCGGCACGAGGATGGCTTTTCCTGTTCACCGATAGTCACGCTGACTATCAGTTAACAACTTTCC
ATTCCGATTTGGCCAACCTCTGCAAGATCGACTGGCCATTGCTTCAAGCGCGCGATTTTCGGCGCGATCAGGAGGACCCG
GCCAAGTTCGAGCGATATCAGGCGGAAGCACTGGTTCACCGACACTTGCCAATCGATGGCCTGCGCGGCATCGTGGGTTA
TACGGACGATATGAAGCTGTCCATCGAGCGTCAACTTAAGGCTCGCAACCTCACACTTCCAGTTCATGCCCGCCCCGAGT
GGTACTTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9299.64 Da        Isoelectric Point: 4.4201

>AT175754 WP_001223210.1 NZ_CP062723:c4962913-4962662 [Escherichia coli O157:H7]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEVQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT175754 NZ_CP082178:3422147-3423178 [Xanthomonas fragariae]
GTGGAGGCATTGGTCAACACTGTCAACACCGTCGGCGTGATGGGCAAAGGCATCGCGCTGATGTTCAAGGAGCGCTTCAA
CGAAAACTTCCTCCGATATGCCGCTGCCTGCAAGGCAAAGCAGGTGCGCACGGGCAAGGTGTTCGTCACCGAAGCCAACG
AACTGGACGGGCCACGCTGGATCATCAATTTTCCGACAAAACAGCACTGGCGTGGCGATTCGCGCATCGAATGGATCACC
GAAGGGCTGCAGGATCTGCGCCTCTTCCTGATCGAGAACAAGGTCGGATCGATTGCCATCCCGCCACTGGGCGCCGGCAA
TGGCGGGTTGGACTGGGCTGACGTGCGTCCACTGATCGAAGAGTCGCTGGCCGGTCTGGATACCGACATTTTCGTGTTCG
AGCCTACCCTGAAGTATCAAAACGTCGCAAAGCGCTCCGGCGTGGAGACGCTGACTCCAGCACGCGCTTTGATTGCCGAA
CTGGTACGTCGCTATTGGGTGCTAGGCGTGGAATGCAGCCTGTTGGAAATCCAGAAGCTGGCATGGTTTCTTGAACGCAA
CATCGAGCGCGCAGGCTTGCCTACGCTGGATTTGCGCTTTGCGCCAAACAAATATGGCCCATATGCCGACCGTCTCCGCC
ATCTGCTGGACGGGCTGGACGGAAGCTATCTGCACTGTGACAAGCGAATCGGCGACGCTGATCCTATAGATGTCATCTGG
TTCGATGACGCTCGCAAAAGCGTTGTCCATGCCTATCTCAAGAGCGAAGCAAAACAGTATGCTCCAGCACTGGAAGCCAC
TGCCGCCTTGATCGATGGTTTTGAAACCCCTTTTGGCATGGAGTTGCTGGCAACGGTGGACTGGCTAATTGCGCAGGGGG
GTGTCTGTCCGCAAGTGGCAGACATGCGCGAGGGCATACGCAACTGGCCCGGTGGCGCTGACGCAGCTGTGCGGAAAGAC
AGATTGTTCGATGACCGCGCTCTAGGCATCGCGTTGGAACGACTGACATCAAGTGCAAGCGCAGTGACTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure

References