Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3633379..3633857 Replicon chromosome
Accession NZ_CP062719
Organism Escherichia coli O157:H7 strain Z1816

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag ILQ55_RS18790 Protein ID WP_001303876.1
Coordinates 3633570..3633857 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag ILQ55_RS18785 Protein ID WP_000536233.1
Coordinates 3633379..3633570 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ55_RS18750 3628783..3629553 - 771 WP_000450992.1 DUF1627 domain-containing protein -
ILQ55_RS18755 3629575..3630321 - 747 WP_000788751.1 ATP-binding protein -
ILQ55_RS18760 3630328..3631419 - 1092 WP_206338777.1 DNA-binding protein -
ILQ55_RS18765 3631498..3631953 + 456 WP_000273724.1 hypothetical protein -
ILQ55_RS18770 3632160..3632585 - 426 WP_000693855.1 Rha family transcriptional regulator -
ILQ55_RS18775 3632569..3632841 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
ILQ55_RS18780 3632950..3633351 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
ILQ55_RS18785 3633379..3633570 + 192 WP_000536233.1 hypothetical protein Antitoxin
ILQ55_RS18790 3633570..3633857 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ILQ55_RS18795 3634135..3634290 + 156 WP_000379575.1 DUF1391 family protein -
ILQ55_RS18800 3634432..3634821 + 390 WP_000394511.1 hypothetical protein -
ILQ55_RS18805 3635008..3635193 - 186 WP_001133046.1 hypothetical protein -
ILQ55_RS18810 3635767..3635955 + 189 WP_000413705.1 cell division inhibition protein DicB -
ILQ55_RS18815 3635952..3636143 + 192 WP_001098307.1 DUF1482 family protein -
ILQ55_RS18820 3636237..3638708 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T175674 WP_001303876.1 NZ_CP062719:3633570-3633857 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T175674 NZ_CP082128:c123439-123041 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTTACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTTAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCCGCTGCAGCCATACACACC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCTG
TCGGGGGCTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGGCGGCCTGAGAATTGAAGACTGGAGCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT175674 WP_000536233.1 NZ_CP062719:3633379-3633570 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT175674 NZ_CP082128:c123666-123439 [Escherichia coli]
ATGGAAACCACCGTATTTCTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTATCGGACGAACCCGACTCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAGCGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAACGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References