Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2592712..2593183 | Replicon | chromosome |
| Accession | NZ_CP062719 | ||
| Organism | Escherichia coli O157:H7 strain Z1816 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | ILQ55_RS13055 | Protein ID | WP_001303511.1 |
| Coordinates | 2592712..2592990 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | ILQ55_RS13060 | Protein ID | WP_001302048.1 |
| Coordinates | 2592992..2593183 (-) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ILQ55_RS13020 | 2587718..2587902 | - | 185 | Protein_2542 | DUF3596 domain-containing protein | - |
| ILQ55_RS13025 | 2587937..2588188 | - | 252 | WP_000005552.1 | excisionase family protein | - |
| ILQ55_RS13030 | 2588261..2590732 | - | 2472 | WP_000048458.1 | exonuclease | - |
| ILQ55_RS13035 | 2590825..2591016 | - | 192 | WP_001090200.1 | DUF1482 family protein | - |
| ILQ55_RS13040 | 2591013..2591201 | - | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| ILQ55_RS13045 | 2591770..2591988 | - | 219 | WP_001171930.1 | hypothetical protein | - |
| ILQ55_RS13050 | 2592060..2592359 | - | 300 | WP_001240334.1 | hypothetical protein | - |
| ILQ55_RS13055 | 2592712..2592990 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| ILQ55_RS13060 | 2592992..2593183 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| ILQ55_RS13065 | 2593204..2593575 | - | 372 | WP_001169686.1 | hypothetical protein | - |
| ILQ55_RS13070 | 2593673..2593975 | + | 303 | WP_000172738.1 | transcriptional regulator | - |
| ILQ55_RS13075 | 2593972..2594397 | + | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
| ILQ55_RS13080 | 2594420..2595382 | + | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| ILQ55_RS13085 | 2595389..2596129 | + | 741 | WP_000788938.1 | ATP-binding protein | - |
| ILQ55_RS13090 | 2596155..2596924 | + | 770 | Protein_2556 | DUF1627 domain-containing protein | - |
| ILQ55_RS13095 | 2596940..2597335 | + | 396 | WP_001118159.1 | DUF977 family protein | - |
| ILQ55_RS13100 | 2597392..2597976 | + | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | nleA/espI | 2572704..2635485 | 62781 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T175667 WP_001303511.1 NZ_CP062719:c2592990-2592712 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T175667 NZ_CP082127:c3828277-3827879 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT175667 WP_001302048.1 NZ_CP062719:c2593183-2592992 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT175667 NZ_CP082127:c3828573-3828280 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|