Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3619978..3620456 Replicon chromosome
Accession NZ_CP062717
Organism Escherichia coli O157:H7 strain Z1825

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag ILQ56_RS18710 Protein ID WP_001303876.1
Coordinates 3620169..3620456 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag ILQ56_RS18705 Protein ID WP_000536233.1
Coordinates 3619978..3620169 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ56_RS18670 3615382..3616152 - 771 WP_000450992.1 DUF1627 domain-containing protein -
ILQ56_RS18675 3616174..3616920 - 747 WP_000788751.1 ATP-binding protein -
ILQ56_RS18680 3616927..3618018 - 1092 WP_001205823.1 hypothetical protein -
ILQ56_RS18685 3618097..3618552 + 456 WP_000273724.1 hypothetical protein -
ILQ56_RS18690 3618759..3619184 - 426 WP_000693855.1 Rha family transcriptional regulator -
ILQ56_RS18695 3619168..3619440 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
ILQ56_RS18700 3619549..3619950 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
ILQ56_RS18705 3619978..3620169 + 192 WP_000536233.1 hypothetical protein Antitoxin
ILQ56_RS18710 3620169..3620456 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ILQ56_RS18715 3620734..3620889 + 156 WP_000379575.1 DUF1391 family protein -
ILQ56_RS18720 3621031..3621420 + 390 WP_000394511.1 hypothetical protein -
ILQ56_RS18725 3621607..3621792 - 186 WP_001133046.1 hypothetical protein -
ILQ56_RS18730 3622366..3622554 + 189 WP_000413705.1 cell division inhibition protein DicB -
ILQ56_RS18735 3622551..3622742 + 192 WP_001098307.1 DUF1482 family protein -
ILQ56_RS18740 3622836..3625307 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T175638 WP_001303876.1 NZ_CP062717:3620169-3620456 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T175638 NZ_CP082120:3541528-3541746 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT175638 WP_000536233.1 NZ_CP062717:3619978-3620169 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT175638 NZ_CP082120:3541128-3541502 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References