Detailed information of TA system TA175602

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 3597556..3598034
• Replicon: chromosome
• Accession: NZ_CP062715
• Organism: Escherichia coli O157:H7 strain Z1826

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A891SFN9
• Locus tag: ILQ57_RS18530
• Protein ID: WP_001303876.1
• Coordinates: 3597747..3598034 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: Q8XD67
• Locus tag: ILQ57_RS18525
• Protein ID: WP_000536233.1
• Coordinates: 3597556..3597747 (+)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ILQ57_RS18490	3592960..3593730	-	771	WP_000450992.1	DUF1627 domain-containing protein	-
ILQ57_RS18495	3593752..3594498	-	747	WP_000788751.1	ATP-binding protein	-
ILQ57_RS18500	3594505..3595596	-	1092	WP_001205823.1	hypothetical protein	-
ILQ57_RS18505	3595675..3596130	+	456	WP_000273724.1	hypothetical protein	-
ILQ57_RS18510	3596337..3596762	-	426	WP_000693855.1	Rha family transcriptional regulator	-
ILQ57_RS18515	3596746..3597018	-	273	WP_000887453.1	helix-turn-helix domain-containing protein	-
ILQ57_RS18520	3597127..3597528	+	402	WP_000986592.1	helix-turn-helix domain-containing protein	-
ILQ57_RS18525	3597556..3597747	+	192	WP_000536233.1	hypothetical protein	Antitoxin
ILQ57_RS18530	3597747..3598034	+	288	WP_001303876.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ILQ57_RS18535	3598312..3598467	+	156	WP_000379575.1	DUF1391 family protein	-
ILQ57_RS18540	3598609..3598998	+	390	WP_000394511.1	hypothetical protein	-
ILQ57_RS18545	3599185..3599370	-	186	WP_001133046.1	hypothetical protein	-
ILQ57_RS18550	3599944..3600132	+	189	WP_000413705.1	cell division inhibition protein DicB	-
ILQ57_RS18555	3600129..3600320	+	192	WP_001098307.1	DUF1482 family protein	-
ILQ57_RS18560	3600414..3602885	+	2472	WP_000034474.1	exonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10978.84 Da
• Isoelectric Point: 10.1360

>T175602 WP_001303876.1 NZ_CP062715:3597747-3598034 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Nucleotide

• Length: 288 bp

>T175602 NZ_CP082037:c4760140-4759607 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7025.80 Da
• Isoelectric Point: 4.0270

>AT175602 WP_000536233.1 NZ_CP062715:3597556-3597747 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Nucleotide

• Length: 192 bp

>AT175602 NZ_CP082037:c4760417-4760151 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA