Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3386190..3386985 Replicon chromosome
Accession NZ_CP062715
Organism Escherichia coli O157:H7 strain Z1826

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag ILQ57_RS17430 Protein ID WP_000854914.1
Coordinates 3386190..3386564 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag ILQ57_RS17435 Protein ID WP_001280954.1
Coordinates 3386611..3386985 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ57_RS17390 3381194..3381685 - 492 WP_001301587.1 DUF1097 domain-containing protein -
ILQ57_RS17395 3381787..3382341 - 555 WP_001001917.1 molecular chaperone YcdY -
ILQ57_RS17400 3382365..3383102 - 738 WP_000283664.1 zinc-binding phosphatase -
ILQ57_RS17405 3383157..3384095 - 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
ILQ57_RS17415 3384566..3385408 - 843 WP_001280481.1 DUF4942 domain-containing protein -
ILQ57_RS17420 3385493..3385690 - 198 WP_000839282.1 DUF957 domain-containing protein -
ILQ57_RS17425 3385702..3386193 - 492 WP_000976853.1 hypothetical protein -
ILQ57_RS17430 3386190..3386564 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
ILQ57_RS17435 3386611..3386985 - 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ILQ57_RS17440 3387148..3387369 - 222 WP_001220314.1 DUF987 domain-containing protein -
ILQ57_RS17445 3387432..3387908 - 477 WP_001186738.1 RadC family protein -
ILQ57_RS17450 3387924..3388409 - 486 WP_000214398.1 antirestriction protein -
ILQ57_RS17455 3388500..3389318 - 819 WP_001234682.1 DUF945 domain-containing protein -
ILQ57_RS17460 3389658..3390728 - 1071 WP_000102669.1 patatin-like phospholipase family protein -
ILQ57_RS17465 3390725..3391630 - 906 WP_000203541.1 chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T175599 WP_000854914.1 NZ_CP062715:c3386564-3386190 [Escherichia coli O157:H7]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T175599 NZ_CP082037:2022798-2022900 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT175599 WP_001280954.1 NZ_CP062715:c3386985-3386611 [Escherichia coli O157:H7]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT175599 NZ_CP082037:c2022907-2022762 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References