Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3760404..3761109 Replicon chromosome
Accession NZ_CP062705
Organism Escherichia coli O157:H7 strain Z1833

Toxin (Protein)


Gene name relE Uniprot ID Q8X3N0
Locus tag ILQ61_RS19235 Protein ID WP_000539519.1
Coordinates 3760404..3760790 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag ILQ61_RS19240 Protein ID WP_001280945.1
Coordinates 3760780..3761109 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ61_RS19215 3756408..3757034 + 627 WP_001295292.1 glutathione S-transferase GstB -
ILQ61_RS19220 3757031..3758146 - 1116 WP_000554959.1 aldose sugar dehydrogenase YliI -
ILQ61_RS19225 3758257..3758640 - 384 WP_000497137.1 biofilm formation regulator BssR -
ILQ61_RS19230 3758853..3760178 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
ILQ61_RS19235 3760404..3760790 + 387 WP_000539519.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ILQ61_RS19240 3760780..3761109 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
ILQ61_RS19245 3761179..3762507 - 1329 WP_000086905.1 GGDEF domain-containing protein -
ILQ61_RS19250 3762515..3764863 - 2349 WP_000950320.1 EAL domain-containing protein -
ILQ61_RS19255 3765041..3765952 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14279.42 Da        Isoelectric Point: 9.9296

>T175455 WP_000539519.1 NZ_CP062705:3760404-3760790 [Escherichia coli O157:H7]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGSKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T175455 NZ_CP082001:354639-354986 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT175455 WP_001280945.1 NZ_CP062705:3760780-3761109 [Escherichia coli O157:H7]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT175455 NZ_CP082001:354986-355285 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References