Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3594250..3594728 Replicon chromosome
Accession NZ_CP062705
Organism Escherichia coli O157:H7 strain Z1833

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag ILQ61_RS18495 Protein ID WP_001303876.1
Coordinates 3594441..3594728 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag ILQ61_RS18490 Protein ID WP_000536233.1
Coordinates 3594250..3594441 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ61_RS18455 3589654..3590424 - 771 WP_000450992.1 DUF1627 domain-containing protein -
ILQ61_RS18460 3590446..3591192 - 747 WP_000788751.1 ATP-binding protein -
ILQ61_RS18465 3591199..3592290 - 1092 WP_001205823.1 hypothetical protein -
ILQ61_RS18470 3592369..3592824 + 456 WP_000273724.1 hypothetical protein -
ILQ61_RS18475 3593031..3593456 - 426 WP_000693855.1 Rha family transcriptional regulator -
ILQ61_RS18480 3593440..3593712 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
ILQ61_RS18485 3593821..3594222 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
ILQ61_RS18490 3594250..3594441 + 192 WP_000536233.1 hypothetical protein Antitoxin
ILQ61_RS18495 3594441..3594728 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ILQ61_RS18500 3595006..3595161 + 156 WP_000379575.1 DUF1391 family protein -
ILQ61_RS18505 3595303..3595692 + 390 WP_000394511.1 hypothetical protein -
ILQ61_RS18510 3595879..3596064 - 186 WP_001133046.1 hypothetical protein -
ILQ61_RS18515 3596638..3596826 + 189 WP_000413705.1 cell division inhibition protein DicB -
ILQ61_RS18520 3596823..3597014 + 192 WP_001098307.1 DUF1482 family protein -
ILQ61_RS18525 3597108..3599579 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T175454 WP_001303876.1 NZ_CP062705:3594441-3594728 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T175454 NZ_CP082001:328668-329036 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT175454 WP_000536233.1 NZ_CP062705:3594250-3594441 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT175454 NZ_CP082001:328450-328671 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References