Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1784..2343 Replicon plasmid pZ1834-1
Accession NZ_CP062703
Organism Escherichia coli O157:H7 strain Z1834

Toxin (Protein)


Gene name relE Uniprot ID O82928
Locus tag ILQ62_RS27030 Protein ID WP_000421248.1
Coordinates 2068..2343 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C1J8K5
Locus tag ILQ62_RS27025 Protein ID WP_001178089.1
Coordinates 1784..2068 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ62_RS27020 13..870 + 858 WP_000130945.1 incFII family plasmid replication initiator RepA -
ILQ62_RS27025 1784..2068 + 285 WP_001178089.1 ribbon-helix-helix domain-containing protein Antitoxin
ILQ62_RS27030 2068..2343 + 276 WP_000421248.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ILQ62_RS27035 2438..2644 + 207 WP_001105064.1 hypothetical protein -
ILQ62_RS27040 2744..2959 - 216 Protein_5 transposase -
ILQ62_RS27045 3003..3569 - 567 Protein_6 IS3-like element IS600 family transposase -
ILQ62_RS27050 3569..3985 - 417 Protein_7 IS91 family transposase -
ILQ62_RS27055 3985..4170 - 186 WP_001302179.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katA / espP / stcE / exeE / exeG / hlyC / hlyA / hlyB / hlyD / toxB 1..95141 95141


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10735.42 Da        Isoelectric Point: 9.9324

>T175427 WP_000421248.1 NZ_CP062703:2068-2343 [Escherichia coli O157:H7]
MELKWSSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T175427 NZ_CP081943:3721503-3721781 [Pseudomonas sp. MM213]
ATGATCAAATCCTTTCAGCACAAAGGCCTTCGCGGTTTCTATGAAACAGGTTCGACGCGTGGAATCCGGGCAAACCATGC
AAAGCGTCTGTCTCGGATGCTGCAATTCATGGACCGCGCAATGGCACCGGGTGACCTCGATCTACCGGGATGGCGATTAC
ACCCGCTCAGGGGCGAATTGGCCGAGTTCTGGGCACTGAGCGTTTCAGGAAACTGGCGGGTTATTTTTCGTTTTATCGGT
TCGGATATCGAGTTGGTCGACTATCTGGACTACCACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10474.89 Da        Isoelectric Point: 5.6558

>AT175427 WP_001178089.1 NZ_CP062703:1784-2068 [Escherichia coli O157:H7]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp

>AT175427 NZ_CP081943:3721795-3722082 [Pseudomonas sp. MM213]
ATGCCCTTGCACAACCCGCCACACCCTGGCGAAACACTGTTGATGGACGTCCTGCCCGAACTGGGCATCAGCGTGACGGA
ACTTGCCCGGCATTTGGGGTTTGCACGCCCTCACCTTTCGCGGGTGCTGCATGGCCATGCGCCGATCAGTCCAGACCTGG
CAGTCCGTCTGGAGCGGGCCGGAATTGGTAAGGCGCGGATGTGGCTAGGGGTTCAGACCGACTACGATCTCTGGCAAGCA
GAGCAGCGGGAGCAACCGGTCATCAAACCCCTCGCAGTCCACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z6FAZ0

Antitoxin

Source ID Structure
AlphaFold DB A0A731IHA8

References