Detailed information of TA system
Overview
TA module
| Type | V | Classification (family/domain) | ghoTS/ghoT-GhoS |
| Location | 4992984..4993481 | Replicon | chromosome |
| Accession | NZ_CP062702 | ||
| Organism | Escherichia coli O157:H7 strain Z1834 | ||
Toxin (Protein)
| Gene name | ghoT | Uniprot ID | L4JJG6 |
| Locus tag | ILQ62_RS24660 | Protein ID | WP_001173343.1 |
| Coordinates | 4992984..4993157 (-) | Length | 58 a.a. |
Antitoxin (Protein)
| Gene name | ghoS | Uniprot ID | L4JK92 |
| Locus tag | ILQ62_RS24665 | Protein ID | WP_000398619.1 |
| Coordinates | 4993185..4993481 (-) | Length | 99 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ILQ62_RS24650 | 4989654..4991111 | + | 1458 | WP_000856824.1 | dipeptide/tripeptide permease DtpC | - |
| ILQ62_RS24655 | 4991348..4992865 | + | 1518 | WP_001295074.1 | lysine--tRNA ligase | - |
| ILQ62_RS24660 | 4992984..4993157 | - | 174 | WP_001173343.1 | type V toxin-antitoxin system toxin GhoT | Toxin |
| ILQ62_RS24665 | 4993185..4993481 | - | 297 | WP_000398619.1 | type V toxin-antitoxin system endoribonuclease antitoxin GhoS | Antitoxin |
| ILQ62_RS24670 | 4993708..4993980 | - | 273 | WP_000405647.1 | N-acetyltransferase | - |
| ILQ62_RS24675 | 4993992..4994222 | - | 231 | WP_000371704.1 | (4Fe-4S)-binding protein | - |
| ILQ62_RS24680 | 4994403..4996034 | + | 1632 | WP_001216477.1 | sensor histidine kinase | - |
| ILQ62_RS24685 | 4996031..4996750 | + | 720 | WP_000611288.1 | two-component system response regulator DcuR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 58 a.a. Molecular weight: 6555.06 Da Isoelectric Point: 10.2288
>T175426 WP_001173343.1 NZ_CP062702:c4993157-4992984 [Escherichia coli O157:H7]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF
Download Length: 174 bp
>T175426 NZ_CP081942:2658354-2658923 [Pseudomonas sp. MM211]
ATGTTCAAGCCGCAGTTGATCACCTTGCAACGTGGTGCCCTGCGCATCGAGCCGCTGCTCGACGGCGATATTCCTGCGTT
GGTGACGCTGGCTGAAGTCAACCGCTCTGAACTGGCCTACATGAGCGGCACCCGGCGCCTGGACTGGTATCGCCAGGCCC
TGCACGAGCAGCGTGAGGATCGCGCGTTGCCCTTCGTGATTCGCCTGGGCGATCAGTTGGTCGGCACGACCCGCTTCGCC
GATTTCATACCGACCTTGCCCGCTGTGGAAATCGGCTGGACCTGGCTGGACGCCAGCCAGCACGGCACCGGGCTCAACAG
CATGATCAAGTACCTGATGCTGCGTCATGCCTTTGAAAGCTGGCGGATGGTTCGTGTGCAACTGAAGACTGCTGGCAGCA
ATTTGCGCTCCCAGCGCGCTATCGAAAAACTCGGCGCCATTCGCGAAGGGCTGCTGCGTAATCATCGCCGCCTGGCTGAC
GGGCGTCTCGACGATACCGTGATGTACAGCATCACCGATCATGAGTGGCCGGTGGTTAAGGCCGGTCTGGAGGCGCGCTT
CGGCGTTTGA
ATGTTCAAGCCGCAGTTGATCACCTTGCAACGTGGTGCCCTGCGCATCGAGCCGCTGCTCGACGGCGATATTCCTGCGTT
GGTGACGCTGGCTGAAGTCAACCGCTCTGAACTGGCCTACATGAGCGGCACCCGGCGCCTGGACTGGTATCGCCAGGCCC
TGCACGAGCAGCGTGAGGATCGCGCGTTGCCCTTCGTGATTCGCCTGGGCGATCAGTTGGTCGGCACGACCCGCTTCGCC
GATTTCATACCGACCTTGCCCGCTGTGGAAATCGGCTGGACCTGGCTGGACGCCAGCCAGCACGGCACCGGGCTCAACAG
CATGATCAAGTACCTGATGCTGCGTCATGCCTTTGAAAGCTGGCGGATGGTTCGTGTGCAACTGAAGACTGCTGGCAGCA
ATTTGCGCTCCCAGCGCGCTATCGAAAAACTCGGCGCCATTCGCGAAGGGCTGCTGCGTAATCATCGCCGCCTGGCTGAC
GGGCGTCTCGACGATACCGTGATGTACAGCATCACCGATCATGAGTGGCCGGTGGTTAAGGCCGGTCTGGAGGCGCGCTT
CGGCGTTTGA
Antitoxin
Download Length: 99 a.a. Molecular weight: 11467.97 Da Isoelectric Point: 4.1705
>AT175426 WP_000398619.1 NZ_CP062702:c4993481-4993185 [Escherichia coli O157:H7]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK
Download Length: 297 bp
>AT175426 NZ_CP081942:2658930-2659772 [Pseudomonas sp. MM211]
ATGGACTCCGGTGAACGCACCCGTTTCTGGGAAAGCTCCGCACTGGCTGGGGTGGAGCTGCTCCAGGCGCGTTATATCAA
ACAGCGCTTCACCCCGCATGTGCACGAAGGTTTCGTGTTCACCGTGATCGAGCACGGCGCGCAGCGTTTCCGCCATCGTG
GCGCCGACCATCTGGCCCCCATCGGTAGCATGGTGCTGATCAATCCGGATGAAGTGCACACCGGTTCGGCGGCCCACGAG
CAGGGTTGGTTCTACCGGGCGTTCTATCCGGCCCCTGCGCAGGTGAATGGTGTGCTCGAAGAGTTGGGGCTGGCCCAGCG
CGGCCTGCCTTCATTTGCCGCCAGCGTGCTGCAGGATGTGCAACTGCATCAGGCATTTGGGCAGTTGCATCGCCTGCTCG
ACAGCGAAGCGAGTAAGCTGCAGCAGCAGACTGCATGGCGGGAAACGCTGCTGATGCTGTTCCAGCGGCATGCGGGTGTT
AGCCAGGCGCCGCTGCCTGGCCAGGAGCCCCGTGCGGTGACTTTGGCCAAGGAACTGCTCGCCTCGCGACTGGGCGAGCC
ACCTTCCCTGGAAGAGCTGGCCGCTGCGGTGAATCTCTCGCCCTTCCATTTCGCCCGGGTGTTCCGCCGCTCGACGGGCC
TGCCGCCCCACGCCTGGCTGCAACTGCGCCGATTGGAGCAAGCACGAGCGCTGCTGCGCGATGGTTGTGCACCGCTGAAT
GTCGCCTTGCAGCTGGGTTTCTCCGACCAGAGCCACCTTGGGCGGCAGTTCAAGCAGGCTTATGGCGTAGCGCCCGGCGA
ATACCGCAACGCCTGCCAACGCAGCCCCGTAGCCTGTGGTTGA
ATGGACTCCGGTGAACGCACCCGTTTCTGGGAAAGCTCCGCACTGGCTGGGGTGGAGCTGCTCCAGGCGCGTTATATCAA
ACAGCGCTTCACCCCGCATGTGCACGAAGGTTTCGTGTTCACCGTGATCGAGCACGGCGCGCAGCGTTTCCGCCATCGTG
GCGCCGACCATCTGGCCCCCATCGGTAGCATGGTGCTGATCAATCCGGATGAAGTGCACACCGGTTCGGCGGCCCACGAG
CAGGGTTGGTTCTACCGGGCGTTCTATCCGGCCCCTGCGCAGGTGAATGGTGTGCTCGAAGAGTTGGGGCTGGCCCAGCG
CGGCCTGCCTTCATTTGCCGCCAGCGTGCTGCAGGATGTGCAACTGCATCAGGCATTTGGGCAGTTGCATCGCCTGCTCG
ACAGCGAAGCGAGTAAGCTGCAGCAGCAGACTGCATGGCGGGAAACGCTGCTGATGCTGTTCCAGCGGCATGCGGGTGTT
AGCCAGGCGCCGCTGCCTGGCCAGGAGCCCCGTGCGGTGACTTTGGCCAAGGAACTGCTCGCCTCGCGACTGGGCGAGCC
ACCTTCCCTGGAAGAGCTGGCCGCTGCGGTGAATCTCTCGCCCTTCCATTTCGCCCGGGTGTTCCGCCGCTCGACGGGCC
TGCCGCCCCACGCCTGGCTGCAACTGCGCCGATTGGAGCAAGCACGAGCGCTGCTGCGCGATGGTTGTGCACCGCTGAAT
GTCGCCTTGCAGCTGGGTTTCTCCGACCAGAGCCACCTTGGGCGGCAGTTCAAGCAGGCTTATGGCGTAGCGCCCGGCGA
ATACCGCAACGCCTGCCAACGCAGCCCCGTAGCCTGTGGTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9QI41 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 2LLZ | |
| AlphaFold DB | A0A7U9QBH6 |