Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 3611484..3613204 Replicon chromosome
Accession NZ_CP062702
Organism Escherichia coli O157:H7 strain Z1834

Toxin (Protein)


Gene name pmenT Uniprot ID A0A7U9J2A7
Locus tag ILQ62_RS18390 Protein ID WP_000312833.1
Coordinates 3611484..3612140 (+) Length 219 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID B7UP19
Locus tag ILQ62_RS18395 Protein ID WP_000634203.1
Coordinates 3612137..3613204 (+) Length 356 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ62_RS18375 3607468..3607644 + 177 WP_001056893.1 hypothetical protein -
ILQ62_RS18380 3607684..3610122 + 2439 WP_000985462.1 type I restriction-modification system subunit M -
ILQ62_RS18385 3610122..3611471 + 1350 WP_000228011.1 restriction endonuclease subunit S -
ILQ62_RS18390 3611484..3612140 + 657 WP_000312833.1 DUF4433 domain-containing protein Toxin
ILQ62_RS18395 3612137..3613204 + 1068 WP_000634203.1 macro domain-containing protein Antitoxin
ILQ62_RS18400 3613223..3616318 + 3096 WP_001688437.1 HsdR family type I site-specific deoxyribonuclease -
ILQ62_RS18405 3616318..3617034 + 717 WP_001122107.1 M48 family metallopeptidase -
ILQ62_RS18410 3617505..3617879 - 375 WP_000171781.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3604421..3617879 13458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(17-217)

Antitoxin

Macro domain

(18-129)


Sequences

Toxin        


Download         Length: 219 a.a.        Molecular weight: 25233.56 Da        Isoelectric Point: 6.2145

>T175418 WP_000312833.1 NZ_CP062702:3611484-3612140 [Escherichia coli O157:H7]
MAYDYSASLNPQKALIWRIVHRDNIPWILDNGLHCGNSLVQAENWINIGNPELIGKRAGHPVPVGTGGTLHDYVPFYFTP
FSPMLMNIHSGRGGIKQRPNEEIVILVSNLRNVAAHDVPFVFTDSHAYYNWTNYYTSLDSLDQIDWPILQARDFRRDPDD
PAKFERYQAEALIWQHCPISLLDGIICYSEEVRLQLEQWLFQRNLTMSVHTRAGWYFS

Download         Length: 657 bp

>T175418 NZ_CP081939:338641-338946 [Avibacterium paragallinarum]
ATGTTTAATTTAACGGCTAAGCATTTTAAAGATGATTATCTTTATCGTTTTTTCCAATATGGCGAATTACATAGCAAAAT
TCCGATGACGTTAAGCAAAGTCTTAGCAAGAAAATTGGATATGATAAATGCCGCAGAAAATCTAAATGATTTGCGTAGTC
CACCTGCTAACCGTTTGGAATTATTAGAACCTAAAGAAAATAAACGTTATTCCATTCGAGTGAATAAACAATATCGTTTA
ATATTCCACTTTGATAATGGCGAGCTTTCTCAACTTTATCTCGATCCTCATCGTTATGATTTATAA

Antitoxin


Download         Length: 356 a.a.        Molecular weight: 40672.70 Da        Isoelectric Point: 5.6927

>AT175418 WP_000634203.1 NZ_CP062702:3612137-3613204 [Escherichia coli O157:H7]
MITYTQGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPENMKVYALACKQKQVITGKMFITETGELMGPRWIVNFPTK
QHWRADSRMEWIEDGLQDLRRFLIEENVQSIAIPPLGAGNGGLNWPDVRAQIESALGDLQDVDILIYQPTEKYQNVAKST
GVKKLTPARAAIAELVRRYWVLGMECSLLEIQKLAWLLQRAIEQHQQDDILKLRFEAHYYGPYAPNLNHLLNALDGTYLK
AEKRIPDSQPLDVIWFNDQKKEHVNAYLNNEAREWLPALEQVSQLIDGFESPFGLELLATVDWLLSRGECQPTLDSVKEG
LHQWPAGERWASRKLRLFDNNNLQFAINRVMEFHC

Download         Length: 1068 bp

>AT175418 NZ_CP081939:338956-339276 [Avibacterium paragallinarum]
ATGTTCCCAACGCAACGTAAGCCCACTTCGGTAGGAGAAATTCTGCAAGAAGAATTTTTACTTCCGCTTAATCTTAAAAT
CAATGACCTTGCCGAAATTCTTGATGTTCACCGTAATACGGCAAGCAACTTAGTGAGTAACCATTCTAAAGTAACCTTAG
AAATGGCAGTCAAATTAGCAAAAGCTTTTGGAACAAGCCCTGAGTTTTGGATAAATCTACAAAATGCTGTAGATTTGTGG
GAGCTTAACCATAATGATCGTTTTCAGCAGAGTTTGAGTAAAGTAAAGATTGCTCATTATCCCCCAGCATTTTCCGTATA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9J2A7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9J2B9

References