Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3475771..3476249 Replicon chromosome
Accession NZ_CP062702
Organism Escherichia coli O157:H7 strain Z1834

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag ILQ62_RS17785 Protein ID WP_001303876.1
Coordinates 3475962..3476249 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag ILQ62_RS17780 Protein ID WP_000536233.1
Coordinates 3475771..3475962 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ62_RS17745 3471175..3471945 - 771 WP_000450992.1 DUF1627 domain-containing protein -
ILQ62_RS17750 3471967..3472713 - 747 WP_000788751.1 ATP-binding protein -
ILQ62_RS17755 3472720..3473811 - 1092 WP_001205823.1 hypothetical protein -
ILQ62_RS17760 3473890..3474345 + 456 WP_000273724.1 hypothetical protein -
ILQ62_RS17765 3474552..3474977 - 426 WP_000693855.1 Rha family transcriptional regulator -
ILQ62_RS17770 3474961..3475233 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
ILQ62_RS17775 3475342..3475743 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
ILQ62_RS17780 3475771..3475962 + 192 WP_000536233.1 hypothetical protein Antitoxin
ILQ62_RS17785 3475962..3476249 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ILQ62_RS17790 3476527..3476682 + 156 WP_000379575.1 DUF1391 family protein -
ILQ62_RS17795 3476824..3477213 + 390 WP_000394511.1 hypothetical protein -
ILQ62_RS17800 3477400..3477585 - 186 WP_001133046.1 hypothetical protein -
ILQ62_RS17805 3478159..3478347 + 189 WP_000413705.1 cell division inhibition protein DicB -
ILQ62_RS17810 3478344..3478535 + 192 WP_001098307.1 DUF1482 family protein -
ILQ62_RS17815 3478629..3481100 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T175416 WP_001303876.1 NZ_CP062702:3475962-3476249 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T175416 NZ_CP081939:111440-111730 [Avibacterium paragallinarum]
ATGACCTATAAACTTTCTTTTGATAAACGGGCGTTAAAAGAATGGCATAAATTGGGCGATACCCTACGCCAACAATTTAA
AGCAAAATTAATCGAACGGCTGGAAAATCCCCACGTTTTAAGCGATAAATTGCACGGCTATCAAACGCTTTATAAAATTA
AATTGCGATCAGCGGGCTATCGGCTTGTTTATGATGTCAATGACAATGAAATTAGGGTGATTGTGCTTTCAGTAGGCAAA
AGAGAACGCCTACAAGCCTATAAAAAAGCCCTATCAAGAAAAGCCCAATAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT175416 WP_000536233.1 NZ_CP062702:3475771-3475962 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT175416 NZ_CP081939:111190-111450 [Avibacterium paragallinarum]
ATGGCAATTCAGCAAATTTTAACCCGACACACGGCAAGCATTAGCGACTTGAAAAAAAATCCTATGGGGATTGTATCAGA
GGGAACAGAGCAAGAAGGGGCGATCGCTATTCTAAACCGTAATGAACCCGTGTTTTATTGCGTAAATCCCCGTCTTTTTG
CGGTTATTCAAGAAATCCTTGAAGACAAAGAACTAGGCGAACTCGCCACACAACGCCTTGCAACCCTTGACCCCGTCGAG
GTGCGTTTAGATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References