Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2564567..2565038 | Replicon | chromosome |
| Accession | NZ_CP062702 | ||
| Organism | Escherichia coli O157:H7 strain Z1834 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | ILQ62_RS12825 | Protein ID | WP_001303511.1 |
| Coordinates | 2564567..2564845 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | ILQ62_RS12830 | Protein ID | WP_001302048.1 |
| Coordinates | 2564847..2565038 (-) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ILQ62_RS12790 | 2559573..2559757 | - | 185 | Protein_2501 | DUF3596 domain-containing protein | - |
| ILQ62_RS12795 | 2559792..2560043 | - | 252 | WP_000005552.1 | excisionase family protein | - |
| ILQ62_RS12800 | 2560116..2562587 | - | 2472 | WP_000048458.1 | exonuclease | - |
| ILQ62_RS12805 | 2562680..2562871 | - | 192 | WP_001090200.1 | DUF1482 family protein | - |
| ILQ62_RS12810 | 2562868..2563056 | - | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| ILQ62_RS12815 | 2563625..2563843 | - | 219 | WP_001171930.1 | hypothetical protein | - |
| ILQ62_RS12820 | 2563915..2564214 | - | 300 | WP_072143447.1 | hypothetical protein | - |
| ILQ62_RS12825 | 2564567..2564845 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| ILQ62_RS12830 | 2564847..2565038 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| ILQ62_RS12835 | 2565059..2565430 | - | 372 | WP_001169686.1 | hypothetical protein | - |
| ILQ62_RS12840 | 2565528..2565830 | + | 303 | WP_000172738.1 | transcriptional regulator | - |
| ILQ62_RS12845 | 2565827..2566252 | + | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
| ILQ62_RS12850 | 2566275..2567237 | + | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| ILQ62_RS12855 | 2567244..2567984 | + | 741 | WP_000788938.1 | ATP-binding protein | - |
| ILQ62_RS12860 | 2568010..2568779 | + | 770 | Protein_2515 | DUF1627 domain-containing protein | - |
| ILQ62_RS12865 | 2568795..2569190 | + | 396 | WP_001118159.1 | DUF977 family protein | - |
| ILQ62_RS12870 | 2569247..2569831 | + | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | nleA/espI / nleH2 / nleF | 2549687..2659708 | 110021 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T175409 WP_001303511.1 NZ_CP062702:c2564845-2564567 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T175409 NZ_CP081897:3972053-3972271 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT175409 WP_001302048.1 NZ_CP062702:c2565038-2564847 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT175409 NZ_CP081897:3971652-3972026 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|