Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3503817..3504295 Replicon chromosome
Accession NZ_CP062700
Organism Escherichia coli O157:H7 strain Z1835

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag ILQ63_RS17950 Protein ID WP_001303876.1
Coordinates 3504008..3504295 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag ILQ63_RS17945 Protein ID WP_000536233.1
Coordinates 3503817..3504008 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ63_RS17910 3499203..3499973 - 771 WP_000450992.1 DUF1627 domain-containing protein -
ILQ63_RS17915 3499995..3500741 - 747 WP_000788751.1 ATP-binding protein -
ILQ63_RS17920 3500748..3501857 - 1110 WP_021499850.1 putative primosomal protein I -
ILQ63_RS17925 3501936..3502391 + 456 WP_000273724.1 hypothetical protein -
ILQ63_RS17930 3502598..3503023 - 426 WP_000693855.1 Rha family transcriptional regulator -
ILQ63_RS17935 3503007..3503279 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
ILQ63_RS17940 3503388..3503789 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
ILQ63_RS17945 3503817..3504008 + 192 WP_000536233.1 hypothetical protein Antitoxin
ILQ63_RS17950 3504008..3504295 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ILQ63_RS17955 3504573..3504728 + 156 WP_000379575.1 DUF1391 family protein -
ILQ63_RS17960 3504870..3505259 + 390 WP_000394511.1 hypothetical protein -
ILQ63_RS17965 3505446..3505631 - 186 WP_001133046.1 hypothetical protein -
ILQ63_RS17970 3506205..3506393 + 189 WP_000413705.1 cell division inhibition protein DicB -
ILQ63_RS17975 3506390..3506581 + 192 WP_001098307.1 DUF1482 family protein -
ILQ63_RS17980 3506675..3509146 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T175380 WP_001303876.1 NZ_CP062700:3504008-3504295 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T175380 NZ_CP062700:3504008-3504295 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT175380 WP_000536233.1 NZ_CP062700:3503817-3504008 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT175380 NZ_CP062700:3503817-3504008 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References