Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2765581..2766219 Replicon chromosome
Accession NZ_CP062700
Organism Escherichia coli O157:H7 strain Z1835

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag ILQ63_RS13885 Protein ID WP_000813794.1
Coordinates 2765581..2765757 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag ILQ63_RS13890 Protein ID WP_001270286.1
Coordinates 2765803..2766219 (+) Length 139 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ63_RS13865 2761203..2762414 - 1212 WP_071525382.1 BenE family transporter YdcO -
ILQ63_RS13870 2762467..2763003 + 537 WP_000429145.1 DNA-binding transcriptional regulator SutR -
ILQ63_RS13875 2763076..2765037 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
ILQ63_RS13880 2765129..2765359 - 231 WP_000494244.1 YncJ family protein -
ILQ63_RS13885 2765581..2765757 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
ILQ63_RS13890 2765803..2766219 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
ILQ63_RS13895 2766298..2767704 + 1407 WP_000760654.1 PLP-dependent aminotransferase family protein -
ILQ63_RS13900 2767949..2769094 + 1146 WP_000047432.1 ABC transporter substrate-binding protein -
ILQ63_RS13905 2769112..2770125 + 1014 WP_000220402.1 ABC transporter ATP-binding protein -
ILQ63_RS13910 2770126..2771067 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-57)

Antitoxin

(91-134)


Sequences


Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T175374 WP_000813794.1 NZ_CP062700:2765581-2765757 [Escherichia coli O157:H7]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T175374 NZ_CP081894:341159-341527 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT175374 WP_001270286.1 NZ_CP062700:2765803-2766219 [Escherichia coli O157:H7]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT175374 NZ_CP081894:340941-341162 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6HPB


Antitoxin

Source ID Structure

References