175353

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 3627588..3628471 Replicon chromosome
Accession NZ_CP062699
Organism Pseudomonas taiwanensis strain WRS8

Toxin (Protein)


Gene name - Uniprot ID A0A2K4LSC9
Locus tag ICN73_RS16245 Protein ID WP_012052908.1
Coordinates 3628034..3628471 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID I7C3Q7
Locus tag ICN73_RS16240 Protein ID WP_003250525.1
Coordinates 3627588..3628037 (+) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICN73_RS16215 3623011..3624210 + 1200 WP_014753765.1 sugar transporter -
ICN73_RS16220 3624250..3624834 - 585 WP_014753764.1 LysE family transporter -
ICN73_RS16225 3624886..3625716 - 831 WP_014753763.1 AraC family transcriptional regulator -
ICN73_RS16230 3625765..3626688 - 924 WP_004573727.1 LysR family transcriptional regulator -
ICN73_RS16235 3626792..3627445 + 654 WP_004573726.1 oxygen-insensitive NAD(P)H-dependent nitroreductase NfsB -
ICN73_RS16240 3627588..3628037 + 450 WP_003250525.1 DUF2384 domain-containing protein Antitoxin
ICN73_RS16245 3628034..3628471 + 438 WP_012052908.1 RES family NAD+ phosphorylase Toxin
ICN73_RS16250 3628640..3629794 - 1155 WP_017147726.1 aminotransferase class V-fold PLP-dependent enzyme -
ICN73_RS16255 3629988..3630911 - 924 WP_014753760.1 LysR family transcriptional regulator -
ICN73_RS16260 3631052..3632281 + 1230 WP_014753759.1 acyl-CoA dehydrogenase -
ICN73_RS16265 3632377..3633441 - 1065 WP_041167238.1 TerC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-138)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(33-91)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15944.21 Da        Isoelectric Point: 5.6016

>T175353 WP_012052908.1 NZ_CP062699:3628034-3628471 [Pseudomonas taiwanensis]
VILWRISAYADLSGTGGLRVSGRWHQAGRPVVYAATSPPGAMLEVLVHLEIDPEDFPTTMRLLRIELPDTVSQAQLPALQ
PGWSAQPELTRTLGNRFLDDGSALLLPVPSAIMPSTTNYLFNPRHPQAQSAKIQVEDFTPDSRLF

Download         Length: 438 bp

>T175353 NZ_CP081891:c5232600-5232217 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16956.46 Da        Isoelectric Point: 5.7258

>AT175353 WP_003250525.1 NZ_CP062699:3627588-3628037 [Pseudomonas taiwanensis]
MLAEVLRDNGYHEYRARLQALLDIPELASDFEIHTRITDGFAATWLVKLTERGVLTPVERDQIIPLRTLKSRIERDQPLT
VDESDRLFRSAHITAMAEAVFGEAGKAKRWLSKPKERFSGLTPMQMLTTQQGTTQVEEMLLQIAEGYGL

Download         Length: 450 bp

>AT175353 NZ_CP081891:c5232842-5232600 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K4LSC9

Antitoxin

Source ID Structure
AlphaFold DB I7C3Q7

References