Detailed information of TA system TA175346

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 3078232..3079907
• Replicon: chromosome
• Accession: NZ_CP062500
• Organism: Vibrio sp. Sal10

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: IHV80_RS13580
• Protein ID: WP_192889385.1
• Coordinates: 3078232..3079443 (-)
• Length: 404 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: IHV80_RS13585
• Protein ID: WP_102553259.1
• Coordinates: 3079440..3079907 (-)
• Length: 156 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IHV80_RS13560	3074534..3075574	-	1041	WP_029223240.1	recombinase RecA	-
IHV80_RS13565	3075714..3076208	-	495	WP_192889383.1	nicotinamide-nucleotide amidase	-
IHV80_RS13570	3076625..3076819	-	195	WP_017088307.1	AlpA family phage regulatory protein	-
IHV80_RS13575	3077031..3078086	-	1056	WP_192889384.1	macro domain-containing protein	-
IHV80_RS13580	3078232..3079443	-	1212	WP_192889385.1	hypothetical protein	Toxin
IHV80_RS13585	3079440..3079907	-	468	WP_102553259.1	DUF4065 domain-containing protein	Antitoxin
IHV80_RS13590	3080081..3080788	-	708	WP_192889386.1	hypothetical protein	-
IHV80_RS13595	3080815..3082452	-	1638	WP_192889387.1	RNA-directed DNA polymerase	-
IHV80_RS13600	3082517..3083956	-	1440	WP_192889388.1	restriction endonuclease subunit S	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3077031..3097159	20128

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RelA/SpoT (86-226)

Antitoxin

• Antitoxin SocA-like, Panacea domain (32-123)

Sequences

Toxin

Protein

• Length: 404 a.a.
• Molecular weight: 45514.32 Da
• Isoelectric Point: 5.0526

>T175346 WP_192889385.1 NZ_CP062500:c3079443-3078232 [Vibrio sp. Sal10]
VSNKEKSVVSFLIDDTPSAEQASKTFHDDYELNFQDFLERTVDESAAEDFSYSNNGVKKAGRRLRKKEGDLKSATATIQQ
FRAAHEKPLNTIAYLVGRCCRELGIDVKPVTRLKRLETIIDKLQRKSLDGNTANATCVTNMNDIGGCRAIFPDLMSLELA
ISQLQGTVEKVGRVRIKDIDNYITNQKPNDCGYRSLHVIYRYDHASGKSFNIEAQLRTRLQHLWATTVEIVDILEGTKIK
THSHSANEDKDDLQIKWEELLSIMSRYIADAEGAIELGQEDKDQFSIRLRELNDEINALGRLKTFRILSEKVEACCDDVT
EHVLLMIDENSLELIFSEEFDNYSQAISVYNAAEKVTRSHSGINTLLISTKNMGQLSEAYPNYLGDCASFMLLLQEAMQF
SGS

Nucleotide

• Length: 1212 bp

>T175346 NZ_CP081891:1869314-1869416 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 156 a.a.
• Molecular weight: 17441.84 Da
• Isoelectric Point: 7.5751

>AT175346 WP_102553259.1 NZ_CP062500:c3079907-3079440 [Vibrio sp. Sal10]
MKTYHTYSAVDVALSLLKHAKEQGKCFSNLQLQKLTYVCHGLSLAHFQRPLVVDDVFAWKFGPVVPSVYFRFKSYGANVI
TEQGDVVLDAESESIVKDVVSQLGHLTGPQLVDLTHRDGSPWHQVWDGTHQKVIPDHLIQSHYTQIKQSGRTTSL

Nucleotide

• Length: 468 bp

>AT175346 NZ_CP081891:c1869423-1869278 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT