Detailed information of TA system TA175333

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1504227..1504843
• Replicon: chromosome
• Accession: NZ_CP062473
• Organism: Lentilactobacillus parabuchneri strain KEM

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: ILQ00_RS06760
• Protein ID: WP_057910635.1
• Coordinates: 1504661..1504843 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: ILQ00_RS06755
• Protein ID: WP_057910636.1
• Coordinates: 1504227..1504625 (-)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ILQ00_RS06735	1500051..1500965	+	915	WP_057910640.1	4-hydroxy-tetrahydrodipicolinate synthase	-
ILQ00_RS06740	1501022..1501795	+	774	WP_057910639.1	4-hydroxy-tetrahydrodipicolinate reductase	-
ILQ00_RS06745	1501817..1503004	+	1188	WP_192851637.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
ILQ00_RS06750	1503025..1504104	+	1080	WP_057910637.1	aspartate-semialdehyde dehydrogenase	-
ILQ00_RS06755	1504227..1504625	-	399	WP_057910636.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
ILQ00_RS06760	1504661..1504843	-	183	WP_057910635.1	type II toxin-antitoxin system HicA family toxin	Toxin
ILQ00_RS06765	1505016..1505870	+	855	WP_057910634.1	metallophosphoesterase	-
ILQ00_RS06770	1506300..1508699	+	2400	WP_192851638.1	phosphoketolase family protein	-
ILQ00_RS06775	1508821..1509579	+	759	WP_057910632.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-113)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7053.28 Da
• Isoelectric Point: 10.8513

>T175333 WP_057910635.1 NZ_CP062473:c1504843-1504661 [Lentilactobacillus parabuchneri]
MDSRTIIQMLKHDGWYKVRIHGDHWHFKHPQKLGIVTVPHPRKDIPKGTYNSILKQAGLK

Nucleotide

• Length: 183 bp

>T175333 NZ_CP081890:807841-808251 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14857.02 Da
• Isoelectric Point: 6.2197

>AT175333 WP_057910636.1 NZ_CP062473:c1504625-1504227 [Lentilactobacillus parabuchneri]
MKYLYYALFKKQSDDKIEVTFPDLAPHAATYGTTMSDALHMAHDALEGYLLVVEDLHEKLPKASSPESLTHDTSQLIIPI
EVDTTLAREREDNVSIKKTLTIPKYLNDLGKQKSINFSATLTDALKHKLNIL

Nucleotide

• Length: 399 bp

>AT175333 NZ_CP081890:807594-807860 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA