Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1504227..1504843 Replicon chromosome
Accession NZ_CP062473
Organism Lentilactobacillus parabuchneri strain KEM

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag ILQ00_RS06760 Protein ID WP_057910635.1
Coordinates 1504661..1504843 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag ILQ00_RS06755 Protein ID WP_057910636.1
Coordinates 1504227..1504625 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ00_RS06735 1500051..1500965 + 915 WP_057910640.1 4-hydroxy-tetrahydrodipicolinate synthase -
ILQ00_RS06740 1501022..1501795 + 774 WP_057910639.1 4-hydroxy-tetrahydrodipicolinate reductase -
ILQ00_RS06745 1501817..1503004 + 1188 WP_192851637.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
ILQ00_RS06750 1503025..1504104 + 1080 WP_057910637.1 aspartate-semialdehyde dehydrogenase -
ILQ00_RS06755 1504227..1504625 - 399 WP_057910636.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ILQ00_RS06760 1504661..1504843 - 183 WP_057910635.1 type II toxin-antitoxin system HicA family toxin Toxin
ILQ00_RS06765 1505016..1505870 + 855 WP_057910634.1 metallophosphoesterase -
ILQ00_RS06770 1506300..1508699 + 2400 WP_192851638.1 phosphoketolase family protein -
ILQ00_RS06775 1508821..1509579 + 759 WP_057910632.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-113)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 7053.28 Da        Isoelectric Point: 10.8513

>T175333 WP_057910635.1 NZ_CP062473:c1504843-1504661 [Lentilactobacillus parabuchneri]
MDSRTIIQMLKHDGWYKVRIHGDHWHFKHPQKLGIVTVPHPRKDIPKGTYNSILKQAGLK

Download         Length: 183 bp

>T175333 NZ_CP081890:807841-808251 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14857.02 Da        Isoelectric Point: 6.2197

>AT175333 WP_057910636.1 NZ_CP062473:c1504625-1504227 [Lentilactobacillus parabuchneri]
MKYLYYALFKKQSDDKIEVTFPDLAPHAATYGTTMSDALHMAHDALEGYLLVVEDLHEKLPKASSPESLTHDTSQLIIPI
EVDTTLAREREDNVSIKKTLTIPKYLNDLGKQKSINFSATLTDALKHKLNIL

Download         Length: 399 bp

>AT175333 NZ_CP081890:807594-807860 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References