Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 2679898..2680409 Replicon chromosome
Accession NZ_CP062469
Organism Staphylococcus aureus strain MRSA - AMRF 4

Toxin (Protein)


Gene name TscT Uniprot ID -
Locus tag ILP76_RS13385 Protein ID WP_194085633.1
Coordinates 2679898..2680197 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag ILP76_RS13390 Protein ID WP_001058486.1
Coordinates 2680200..2680409 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILP76_RS13355 2674925..2675503 - 579 WP_000856047.1 hypothetical protein -
ILP76_RS13360 2675538..2675882 - 345 WP_001288441.1 hypothetical protein -
ILP76_RS13365 2676326..2676967 - 642 WP_111724378.1 pathogenicity island protein -
ILP76_RS13370 2676969..2677241 - 273 WP_111724377.1 pathogenicity island protein -
ILP76_RS13375 2677228..2678031 - 804 WP_111724376.1 bifunctional DNA primase/polymerase -
ILP76_RS13380 2678207..2679823 - 1617 WP_111724375.1 phage resistance protein -
ILP76_RS13385 2679898..2680197 - 300 WP_194085633.1 DUF1474 family protein Toxin
ILP76_RS13390 2680200..2680409 - 210 WP_001058486.1 hypothetical protein Antitoxin
ILP76_RS13395 2680402..2680548 - 147 WP_000784875.1 hypothetical protein -
ILP76_RS13400 2680560..2680832 - 273 WP_031903009.1 helix-turn-helix domain-containing protein -
ILP76_RS13405 2680865..2681077 - 213 WP_000608987.1 hypothetical protein -
ILP76_RS13410 2681222..2681917 + 696 WP_031903008.1 helix-turn-helix domain-containing protein -
ILP76_RS13415 2682196..2683410 + 1215 WP_194085634.1 site-specific integrase -
ILP76_RS13420 2683413..2684111 + 699 WP_000608381.1 DUF3800 domain-containing protein -
ILP76_RS13425 2684098..2684724 + 627 WP_000281092.1 hypothetical protein -
ILP76_RS13430 2685056..2685298 - 243 WP_000897044.1 30S ribosomal protein S18 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - seb 2665600..2689916 24316


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11825.27 Da        Isoelectric Point: 4.5689

>T175319 WP_194085633.1 NZ_CP062469:c2680197-2679898 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFDELIQKF
HEIEKTSSDVSLATESDDA

Download         Length: 300 bp

>T175319 NZ_CP081888:c69064-68912 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATTGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8252.31 Da        Isoelectric Point: 4.3718

>AT175319 WP_001058486.1 NZ_CP062469:c2680409-2680200 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT175319 NZ_CP081888:69116-69176 [Escherichia coli]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References