Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2197061..2197538 Replicon chromosome
Accession NZ_CP062469
Organism Staphylococcus aureus strain MRSA - AMRF 4

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag ILP76_RS10930 Protein ID WP_000052076.1
Coordinates 2197350..2197538 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag ILP76_RS10925 Protein ID WP_001059690.1
Coordinates 2197061..2197321 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILP76_RS10890 2192454..2193170 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
ILP76_RS10895 2193318..2193740 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
ILP76_RS10900 2194139..2194633 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
ILP76_RS10905 2194788..2195405 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
ILP76_RS10910 2195478..2196059 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
ILP76_RS10915 2196284..2196520 + 237 WP_000349581.1 hypothetical protein -
ILP76_RS10920 2196517..2196720 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
ILP76_RS10925 2197061..2197321 + 261 WP_001059690.1 hypothetical protein Antitoxin
ILP76_RS10930 2197350..2197538 + 189 WP_000052076.1 hypothetical protein Toxin
ILP76_RS10935 2197726..2198295 + 570 WP_001106654.1 hypothetical protein -
ILP76_RS10940 2198383..2198667 + 285 WP_001004399.1 hypothetical protein -
ILP76_RS10945 2198729..2198947 + 219 WP_000005886.1 hypothetical protein -
ILP76_RS10950 2199439..2199639 - 201 WP_001059082.1 cold-shock protein -
ILP76_RS10955 2199996..2200682 - 687 WP_000141557.1 thermonuclease family protein -
ILP76_RS10960 2201023..2201544 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T175318 WP_000052076.1 NZ_CP062469:2197350-2197538 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T175318 NZ_CP081888:5875-6255 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTGATAGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCTGGCATGTC
AGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTCCAGGCCAGAGTTGTGTACGAAGAGATTACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCCGCGGAGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT175318 WP_001059690.1 NZ_CP062469:2197061-2197321 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT175318 NZ_CP081888:5654-5875 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References