Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1114448..1115224 Replicon chromosome
Accession NZ_CP062469
Organism Staphylococcus aureus strain MRSA - AMRF 4

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag ILP76_RS05630 Protein ID WP_000031108.1
Coordinates 1115072..1115224 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag ILP76_RS05625 Protein ID WP_001251224.1
Coordinates 1114448..1115047 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILP76_RS05605 1110364..1111821 + 1458 WP_000649908.1 ABC transporter permease subunit -
ILP76_RS05610 1111814..1112536 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
ILP76_RS05615 1112687..1113814 + 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
ILP76_RS05620 1113819..1114289 + 471 WP_000181392.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
ILP76_RS05625 1114448..1115047 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
ILP76_RS05630 1115072..1115224 + 153 WP_000031108.1 hypothetical protein Toxin
ILP76_RS05635 1115772..1116167 + 396 WP_000901023.1 hypothetical protein -
ILP76_RS05640 1116363..1117748 + 1386 WP_000116234.1 class II fumarate hydratase -
ILP76_RS05645 1118211..1119032 - 822 WP_000669376.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T175317 WP_000031108.1 NZ_CP062469:1115072-1115224 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T175317 NZ_CP081887:c72421-72272 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT175317 WP_001251224.1 NZ_CP062469:1114448-1115047 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT175317 NZ_CP081887:72465-72526 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References