Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1591536..1592050 Replicon chromosome
Accession NZ_CP062467
Organism Staphylococcus aureus strain MRSA - AMRF 5

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag ILP77_RS07830 Protein ID WP_000581792.1
Coordinates 1591841..1592050 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag ILP77_RS07825 Protein ID WP_000138932.1
Coordinates 1591536..1591829 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILP77_RS07805 1587140..1587781 + 642 WP_000483164.1 thiamine phosphate synthase -
ILP77_RS07810 1587867..1588739 + 873 WP_000725802.1 membrane protein insertase YidC -
ILP77_RS07815 1589211..1589858 - 648 WP_001187629.1 HD domain-containing protein -
ILP77_RS07820 1589886..1591370 - 1485 WP_000571549.1 cardiolipin synthase -
ILP77_RS07825 1591536..1591829 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
ILP77_RS07830 1591841..1592050 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
ILP77_RS07835 1592178..1592315 + 138 WP_000828354.1 hypothetical protein -
ILP77_RS07840 1592579..1593781 - 1203 WP_001109939.1 rod shape-determining protein RodA -
ILP77_RS07845 1594099..1595169 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
ILP77_RS07850 1595184..1596542 + 1359 WP_000611483.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T175288 WP_000581792.1 NZ_CP062467:1591841-1592050 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T175288 NZ_CP081879:176834-177103 [Exiguobacterium acetylicum]
ATGACGACATACAAAGTGGAGTTCGAGCGCGGAGCTCAAAAGTCTCTCAAGAAGATGGATCCCCAACAAACGCGGATCAT
CATGTCCTGGATCAAGAAGAATCTGGTCGGGACGGATGATCCGCGTCGTCATGGTAAGGGACTCGTCTCGAACAGATCGG
GTGAATGGCGTTATCGCATCGGTGATTATCGTCTGATTGCTGACATCCAGGATGAAAAAGTCGTGATCTTAATTCTTGAA
ATCGGTCATCGTCGTGACATTTATAAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT175288 WP_000138932.1 NZ_CP062467:1591536-1591829 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT175288 NZ_CP081879:176613-176837 [Exiguobacterium acetylicum]
ATGAGTACCATTTCCGTACGTTTAGATGATCAGGATACACGACTCATCAAGGAATATGCGAAAGCAAAGAACATCACGAT
TTCCACACTTGTCCGCGATGCCGTCCTCGACCGCATCGAAGATGAGATTGATTTACAACTCTATCATGATTCCATGGCAG
CACACCGTAAAAAATCAGAAGCGATCTCTTTCGACGATATGATGAAGGAACTTGATTTAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References