Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 54368..54845 Replicon chromosome
Accession NZ_CP062467
Organism Staphylococcus aureus strain MRSA - AMRF 5

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag ILP77_RS00405 Protein ID WP_000052076.1
Coordinates 54657..54845 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag ILP77_RS00400 Protein ID WP_001059690.1
Coordinates 54368..54628 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILP77_RS00365 49761..50477 - 717 WP_000150016.1 type I 3-dehydroquinate dehydratase -
ILP77_RS00370 50625..51047 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
ILP77_RS00375 51446..51940 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
ILP77_RS00380 52095..52712 + 618 WP_000255557.1 LysE/ArgO family amino acid transporter -
ILP77_RS00385 52785..53366 - 582 WP_001140695.1 phosphoglycerate mutase family protein -
ILP77_RS00390 53591..53827 + 237 WP_000368687.1 hypothetical protein -
ILP77_RS00395 53824..54027 - 204 WP_000145164.1 sterile alpha motif-like domain-containing protein -
ILP77_RS00400 54368..54628 + 261 WP_001059690.1 hypothetical protein Antitoxin
ILP77_RS00405 54657..54845 + 189 WP_000052076.1 hypothetical protein Toxin
ILP77_RS00410 55033..55602 + 570 WP_001106652.1 hypothetical protein -
ILP77_RS00415 55690..55974 + 285 WP_001004399.1 hypothetical protein -
ILP77_RS00420 56036..56254 + 219 WP_000005886.1 hypothetical protein -
ILP77_RS00425 56750..56950 - 201 WP_001059082.1 cold-shock protein -
ILP77_RS00430 57307..57993 - 687 WP_001793574.1 thermonuclease family protein -
ILP77_RS00435 58334..58855 - 522 WP_000824487.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T175278 WP_000052076.1 NZ_CP062467:54657-54845 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T175278 NZ_CP081865:c4805067-4804783 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT175278 WP_001059690.1 NZ_CP062467:54368-54628 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT175278 NZ_CP081865:c4805299-4805057 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References