Detailed information of TA system TA175277

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2624904..2625415
• Replicon: chromosome
• Accession: NZ_CP062465
• Organism: Staphylococcus aureus strain MRSA - AMRF 6

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: ILP78_RS13140
• Protein ID: WP_194085633.1
• Coordinates: 2624904..2625203 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: ILP78_RS13145
• Protein ID: WP_001058486.1
• Coordinates: 2625206..2625415 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ILP78_RS13110	2619931..2620509	-	579	WP_000856047.1	hypothetical protein	-
ILP78_RS13115	2620544..2620888	-	345	WP_001288441.1	hypothetical protein	-
ILP78_RS13120	2621332..2621973	-	642	WP_111724378.1	pathogenicity island protein	-
ILP78_RS13125	2621975..2622247	-	273	WP_111724377.1	pathogenicity island protein	-
ILP78_RS13130	2622234..2623037	-	804	WP_111724376.1	bifunctional DNA primase/polymerase	-
ILP78_RS13135	2623213..2624829	-	1617	WP_111724375.1	phage resistance protein	-
ILP78_RS13140	2624904..2625203	-	300	WP_194085633.1	DUF1474 family protein	Toxin
ILP78_RS13145	2625206..2625415	-	210	WP_001058486.1	hypothetical protein	Antitoxin
ILP78_RS13150	2625408..2625554	-	147	WP_000784875.1	hypothetical protein	-
ILP78_RS13155	2625566..2625838	-	273	WP_031903009.1	helix-turn-helix domain-containing protein	-
ILP78_RS13160	2625871..2626083	-	213	WP_000608987.1	hypothetical protein	-
ILP78_RS13165	2626228..2626923	+	696	WP_031903008.1	helix-turn-helix domain-containing protein	-
ILP78_RS13170	2627202..2628416	+	1215	WP_194085634.1	site-specific integrase	-
ILP78_RS13175	2628419..2629117	+	699	WP_000608381.1	DUF3800 domain-containing protein	-
ILP78_RS13180	2629104..2629730	+	627	WP_000281092.1	hypothetical protein	-
ILP78_RS13185	2630062..2630304	-	243	WP_000897044.1	30S ribosomal protein S18	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	seb	2611158..2634922	23764

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11825.27 Da
• Isoelectric Point: 4.5689

>T175277 WP_194085633.1 NZ_CP062465:c2625203-2624904 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFDELIQKF
HEIEKTSSDVSLATESDDA

Nucleotide

• Length: 300 bp

>T175277 NZ_CP081865:c4693881-4693348 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT175277 WP_001058486.1 NZ_CP062465:c2625415-2625206 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT175277 NZ_CP081865:c4694158-4693892 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA