Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2143183..2143660 Replicon chromosome
Accession NZ_CP062465
Organism Staphylococcus aureus strain MRSA - AMRF 6

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag ILP78_RS10710 Protein ID WP_000052076.1
Coordinates 2143472..2143660 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag ILP78_RS10705 Protein ID WP_001059690.1
Coordinates 2143183..2143443 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILP78_RS10670 2138576..2139292 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
ILP78_RS10675 2139440..2139862 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
ILP78_RS10680 2140261..2140755 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
ILP78_RS10685 2140910..2141527 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
ILP78_RS10690 2141600..2142181 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
ILP78_RS10695 2142406..2142642 + 237 WP_000349581.1 hypothetical protein -
ILP78_RS10700 2142639..2142842 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
ILP78_RS10705 2143183..2143443 + 261 WP_001059690.1 hypothetical protein Antitoxin
ILP78_RS10710 2143472..2143660 + 189 WP_000052076.1 hypothetical protein Toxin
ILP78_RS10715 2143848..2144417 + 570 WP_001106654.1 hypothetical protein -
ILP78_RS10720 2144505..2144789 + 285 WP_001004399.1 hypothetical protein -
ILP78_RS10725 2144851..2145069 + 219 WP_000005886.1 hypothetical protein -
ILP78_RS10730 2145561..2145761 - 201 WP_001059082.1 cold-shock protein -
ILP78_RS10735 2146118..2146804 - 687 WP_000141557.1 thermonuclease family protein -
ILP78_RS10740 2147145..2147666 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T175276 WP_000052076.1 NZ_CP062465:2143472-2143660 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T175276 NZ_CP081865:4065919-4066137 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT175276 WP_001059690.1 NZ_CP062465:2143183-2143443 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT175276 NZ_CP081865:4065518-4065892 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References