Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 481239..481762 Replicon chromosome
Accession NZ_CP062465
Organism Staphylococcus aureus strain MRSA - AMRF 6

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag ILP78_RS02190 Protein ID WP_000074049.1
Coordinates 481496..481762 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag ILP78_RS02185 Protein ID WP_000587616.1
Coordinates 481239..481496 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILP78_RS02165 476319..477512 + 1194 WP_000675401.1 MFS transporter -
ILP78_RS02170 477736..478485 - 750 WP_000072458.1 hypothetical protein -
ILP78_RS02175 478680..480257 + 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
ILP78_RS02180 480425..480880 - 456 WP_000732076.1 DUF1307 domain-containing protein -
ILP78_RS02185 481239..481496 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ILP78_RS02190 481496..481762 + 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
ILP78_RS02195 482117..483193 + 1077 WP_001076673.1 M42 family metallopeptidase -
ILP78_RS02200 483441..484103 + 663 WP_000923524.1 ATP-binding cassette domain-containing protein -
ILP78_RS02205 484096..484872 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
ILP78_RS02210 485268..486455 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T175262 WP_000074049.1 NZ_CP062465:481496-481762 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T175262 NZ_CP081864:c1036133-1035882 [Symbiopectobacterium purcellii]
ATGAGAACGATCAGTTACAGTGAAGCCCGCCAGAATTTATCAGCAACGATGATGAAAACGGTGGAAGATCACGCCCCCAT
ATTGATTACCCGGCAAAACGGTGAGGCGTGTGTTCTCATGTCCCTGGAAGAGTACAACTCTCTGGAAGAAACCGCCTATC
TGTTACGCTCGCCGGCAAATGCCAAAAGGCTTATGAACGCCATAGAAAGTTTGAAAGCCGGTGAAGGGACAGAAAAGGGC
ATCATCGAATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT175262 WP_000587616.1 NZ_CP062465:481239-481496 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT175262 NZ_CP081864:c1035885-1035631 [Symbiopectobacterium purcellii]
ATGAAGTCAACGTGGTCTGAAGAAGCATGGGAGGATTATCTGTACTGGCAGGATACAGATAATCGCATGGTTAAGAAGAT
CAACGCACTCATTAAAGATGTTTTGAGAACGCCTTTTGAGGGTAAGGGTAAACCTGAGCCCTTGAAACACAATTTGTCCG
GTTTTTGGTCCCGGCGCATCACCGAAGAGCATCGTCTGGTTTATGCCATTGCAGAGGGTGCCATTCTTATAGCCGCCTGC
CGCTACCACTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References