Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2723867..2724381 Replicon chromosome
Accession NZ_CP062439
Organism Staphylococcus aureus strain NAS_AN_285

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF743_RS13580 Protein ID WP_000581792.1
Coordinates 2724172..2724381 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF743_RS13575 Protein ID WP_000138932.1
Coordinates 2723867..2724160 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF743_RS13555 (2719130) 2719130..2719771 + 642 WP_000483153.1 thiamine phosphate synthase -
IF743_RS13560 (2719857) 2719857..2720729 + 873 WP_000725802.1 membrane protein insertase YidC -
IF743_RS13565 (2721542) 2721542..2722189 - 648 WP_001187629.1 HD domain-containing protein -
IF743_RS13570 (2722217) 2722217..2723701 - 1485 WP_000571549.1 cardiolipin synthase -
IF743_RS13575 (2723867) 2723867..2724160 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF743_RS13580 (2724172) 2724172..2724381 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF743_RS13585 (2724509) 2724509..2724646 + 138 WP_000828354.1 Lmo0850 family protein -
IF743_RS13590 (2724910) 2724910..2726112 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF743_RS13595 (2726430) 2726430..2727500 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF743_RS13600 (2727515) 2727515..2728873 + 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T175260 WP_000581792.1 NZ_CP062439:2724172-2724381 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T175260 NZ_CP081864:726814-727245 [Symbiopectobacterium purcellii]
GTGGCCCTGTGGCGCTGTGATTTACGCGTCTCCTGGCGCATGCAGGTATTTTCTTTGCTGGTGCACGGGCCGTTGCTGCT
GTTGATTCTGCTGGCACCGTGGCCGGACGGTTATGCGGTGCTCTGGCTCTCGCTGATGACGCTGGTGGTGTTCGGGTTTA
TCCGCAGCCAGCGTAATATCAAAGCGCGCCACGGCGAAATCGTGTTGCAGGCTGAAGCAAACCTAGAGTGGCAGCATCAT
CGCTGGCGCATTATCCGCCGTCCGTGGATGTTGAAAAACGGTATCTTACTGTCGCTGCGGCGCAGTGACGGCAAGCGGCG
GCAGCGGCTCTGGCTGGCATCAGACAACATGGATAAGCAGGAGTGGCGACACTTGCGCCAGCTGTTGCTGGAGAATAAGG
CGTGGGCGGGAGAAAACCCGGACGCACAGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT175260 WP_000138932.1 NZ_CP062439:2723867-2724160 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT175260 NZ_CP081864:726567-726833 [Symbiopectobacterium purcellii]
ATGGATATCGATAATAAGGCGCGAATTCACTGGGCGTGCCGCCGAGGAATGCGAGAATTGGATATCGCCATCATGCCCTT
TTTTGAACATGAGTATGATGTGCTAAACGATGATGACAAACGCGCTTTTGTGCGTTTATTGCAGTGCGATGACCCTGACC
TGTTCAACTGGTTGATGAACCACGGAGAACCGGAAGATGGGGAACCGAAACGCATGATCTCTCTTATTCAGACGCGAAAT
AAAGATCGTGGCCCTGTGGCGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References