Detailed information of TA system TA175251

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1225695..1226172
• Replicon: chromosome
• Accession: NZ_CP062439
• Organism: Staphylococcus aureus strain NAS_AN_285

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: Q2G005
• Locus tag: IF743_RS06225
• Protein ID: WP_000052078.1
• Coordinates: 1225984..1226172 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: IF743_RS06220
• Protein ID: WP_001059690.1
• Coordinates: 1225695..1225955 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF743_RS06185 (1221088)	1221088..1221804	-	717	WP_000150017.1	type I 3-dehydroquinate dehydratase	-
IF743_RS06190 (1221952)	1221952..1222374	+	423	WP_000974460.1	organic hydroperoxide resistance protein	-
IF743_RS06195 (1222773)	1222773..1223267	+	495	WP_000569884.1	GNAT family N-acetyltransferase	-
IF743_RS06200 (1223422)	1223422..1224039	+	618	WP_000255561.1	LysE/ArgO family amino acid transporter	-
IF743_RS06205 (1224112)	1224112..1224693	-	582	WP_001140686.1	histidine phosphatase family protein	-
IF743_RS06210 (1224918)	1224918..1225154	+	237	WP_000368687.1	hypothetical protein	-
IF743_RS06215 (1225151)	1225151..1225354	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
IF743_RS06220 (1225695)	1225695..1225955	+	261	WP_001059690.1	hypothetical protein	Antitoxin
IF743_RS06225 (1225984)	1225984..1226172	+	189	WP_000052078.1	hypothetical protein	Toxin
IF743_RS06230 (1226360)	1226360..1226929	+	570	WP_001106654.1	lipoprotein N-acylation protein LnsA	-
IF743_RS06235 (1227017)	1227017..1227301	+	285	WP_001004395.1	hypothetical protein	-
IF743_RS06240 (1227363)	1227363..1227581	+	219	WP_084979957.1	hypothetical protein	-
IF743_RS06245 (1228077)	1228077..1228277	-	201	WP_001059082.1	cold-shock protein	-
IF743_RS06250 (1228634)	1228634..1229320	-	687	WP_001548082.1	thermonuclease family protein	-
IF743_RS06255 (1229661)	1229661..1230131	-	471	WP_000824472.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selq / selk / vWbp / vWbp	1200435..1239843	39408

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-65)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7172.84 Da
• Isoelectric Point: 9.9971

>T175251 WP_000052078.1 NZ_CP062439:1225984-1226172 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T175251 NZ_CP081858:467722-468006 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATTGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT175251 WP_001059690.1 NZ_CP062439:1225695-1225955 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT175251 NZ_CP081858:467490-467732 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAGGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAGGATGCACTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Structures

Toxin

• AlphaFold DB: A0A0D6HZ40

Antitoxin

• AlphaFold DB: A0A0E0VN56