Detailed information of TA system TA175243

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2654457..2654986
• Replicon: chromosome
• Accession: NZ_CP062421
• Organism: Staphylococcus aureus strain NAS_AN_003

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: IF693_RS13075
• Protein ID: WP_000621175.1
• Coordinates: 2654624..2654986 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: IF693_RS13070
• Protein ID: WP_000948331.1
• Coordinates: 2654457..2654627 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF693_RS13040 (2649493)	2649493..2650053	+	561	WP_001092409.1	K(+)-transporting ATPase subunit C	-
IF693_RS13045 (2650262)	2650262..2650741	+	480	WP_001287079.1	hypothetical protein	-
IF693_RS13050 (2650734)	2650734..2652317	+	1584	WP_001294620.1	PH domain-containing protein	-
IF693_RS13055 (2652304)	2652304..2652795	+	492	WP_001205912.1	PH domain-containing protein	-
IF693_RS13060 (2652799)	2652799..2653158	+	360	WP_000581197.1	holo-ACP synthase	-
IF693_RS13065 (2653224)	2653224..2654372	+	1149	WP_001281154.1	alanine racemase	-
IF693_RS13070 (2654457)	2654457..2654627	+	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
IF693_RS13075 (2654624)	2654624..2654986	+	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
IF693_RS13080 (2655335)	2655335..2656336	+	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
IF693_RS13085 (2656455)	2656455..2656781	+	327	WP_001052491.1	anti-sigma factor antagonist	-
IF693_RS13090 (2656783)	2656783..2657262	+	480	WP_001190829.1	anti-sigma B factor RsbW	-
IF693_RS13095 (2657237)	2657237..2658007	+	771	WP_001041103.1	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T175243 WP_000621175.1 NZ_CP062421:2654624-2654986 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T175243 NZ_CP081845:c14794-14540 [Caenibius sp. WL]
ATGAACAGCAAGCAGTCCAAGACGCTCAAAGCCATCTTCTCCGATCCGGTTTCGGGAACGATCAAATGGGCGTCTATTGA
AAGTCTGTTCGTCGCGGTCGGTTGCGAAATAATCGAGGGCAAGGGATCGCATGTCCAAGCCCACAAGGATGGCGTGATAG
GTTATTTCGTCCGCCCCCATCCGAACAAGGAGGCCAAGCGCTACCAAATTCGGGATGTGAGGGAATTTCTAGCGAAGATT
GGAGTTGAGCCATGA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT175243 WP_000948331.1 NZ_CP062421:2654457-2654627 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT175243 NZ_CP081845:c14543-14211 [Caenibius sp. WL]
ATGAACGTCATGAGTCACAAAGGTTACAGCGCCCGCATCGAATATGATGATGACGATGGCATTTTTTTCGGCAGGCTTGC
CGGTATCAATGATGTGGTCGGCTTTCATGCCGATAGCGTCGAAGAACTGCGCGCCGCCTTTCACGAGGCCGTGGACGATT
ACATCGAAGCATGCGCGAAGATCGGGAAAGACCCTCAGAAGCCCTATTCCGGCAAGATGATGTTTCGCGTGAGCCCCGAG
CTACATCGCCGGGCGGCCATCGCGGCTGAACTGGCGGGCAAGAGCCTTAACCAGTGGGCGGAGGAAGCCCTGCATGAGGC
GCTTCCTCACTAG

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1